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      • Open Access Article

        1 - Short-term Effect of Aerobic Exercise, High-fat Diet and Curcumin Extract on Interleukin-six Gene Expression in Muscle Tissue of Rats
        Sara Aghayan Tahereh Bagherpour Nematollah Nemati
      • Open Access Article

        2 - Comparison of the Effects of Flaxseed and Nigella Sativa Oils on Liver Enzymes and Some of the Inflammatory Factors in Male Rats with non-Alcoholic Fatty Liver
        Mozhgan Rahimi Seyed Ebrahim Hosseini Mohammad Amin edalatmanesh
        Fatty liver is a common metabolic disorder affecting millions of people all over the world. Due to the side effects of most of the chemical drugs used to treat this disease, this study has been performed aiming to investigate the effect of flaxseed and N. sativa oils on More
        Fatty liver is a common metabolic disorder affecting millions of people all over the world. Due to the side effects of most of the chemical drugs used to treat this disease, this study has been performed aiming to investigate the effect of flaxseed and N. sativa oils on serum levels of liver enzymes and some of the inflammatory factors in in male rats affected by non-alcoholic fatty liver disease (NAFLD). In this experimental study, 40 mature male rats were randomly assigned to 5 groups (8 rats in each group) include the control group (receiving no treatment), fatty liver (treated by fat emulsion), and the experimenta groups under 6-weeks by fat emulsion, and 28-day treatments by 0.75 ml/kg of flaxseed oil, 5 ml/kg of N. sativa oil, and the combined treatmnet of 0.75+ 5 ml/kg of flaxseed and N. sativa oils, respectively. At the end, after blood sampling and separation of the surface serum of aspartate aminotransferase (AST), alanine aminotransferase (ALT), alkaline phosphatase (ALP), BUN (blood urea nitrogen), creatinine, total protein, and interleukin 6 were measured.  Data analysis was done by ANOVA and Tukey tests. The results showed that iduction of fatty liver caused significant increase of interleukin-6, total protein, blood urea nitrogen, ALP, ALT, AST enzymes, and creatinine compared to the control group (P˂0.01); while the use of flaxseed and N. Sativa oils alone and their combination caused a significant decrease in the level of the above mentioend (P˂0.01). factors The results showed that N. sativa and flaxseed oils and their combination can decrease the inflammatory serum factors and liver damage caused by fatty liver disorder. Manuscript profile
      • Open Access Article

        3 - The Effect of Aerobic-Resistance Training Course on Plasma Levels of Neuroglin 1 and Interleukin 6 in Patients with Coronary Artery Bypass Graft
        Amin Zahedi Anaraki Rambad Khaja-ei Amir Rashidlmir Ameneh Barjasteh
        Coronary artery disease is currently one of the leading causes of disability and death worldwide. The present study aims at investigating the effect of eight weeks aerobic-resistance training on neuroglin-1 and interleukin-6 in patients with coronary artery bypass graft More
        Coronary artery disease is currently one of the leading causes of disability and death worldwide. The present study aims at investigating the effect of eight weeks aerobic-resistance training on neuroglin-1 and interleukin-6 in patients with coronary artery bypass grafting. The research method was quasi-experimental and pre-test-post-test. The statistical population was all patients with coronary artery bypass grafting in Mashhad. Height 1.58 ± 0.03 (m), weight 68.11 ± 5.54 (kg), body mass index 27.18 ± 2.47 (2 kg / m2) and disease history 8.75 ± 25/20 (month) was formed after coronary artery bypass surgery. According to the inclusion criteria, they were divided into experimental (12) and control (12) groups. Data was analyzed using independent t-test and paired t-test at the significance level of P≥0.05 and SPSS software version 21. The results of the present study showed that eight weeks aerobic-resistance training increases neuroglin1 (P = 0.001) and insignificantly decreases interleukin 6 in the combination training group compared with the control group (P = 0.061). Statistical results of t-correlated t-test showed a significant increase in neuroglin1 (P = 0.001) and a non-significant decrease in interleukin 6 in the post-test combination test group compared with the pretest (P = 0.889). These changes were not significant in the control group (P = 0.331, P = 0.789. The data of the present study showed that aerobic-resistance training can improve the condition of patients with coronary artery bypass graft by increasing the studied factors. Manuscript profile