List of Articles Inflammatory pain

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  1 - Inhibition of inflammatory pain induced by formalin test by quercetin: role of opioidergic, nitric oxide and histaminergic pathways in mice
  شاهین Hassanpour سارا Zahedi امیر حسام Sarfi
  10.30495/jcp.2023.22821
  The present study was conducted in order to investigate the role of opioidergic, nitric oxide and histaminergic pathways in pain inhibition by quercetin in mice. 85 male mice were randomly evaluated in 5 experimental phases with four groups and 5 repetitions in each gro More

  The present study was conducted in order to investigate the role of opioidergic, nitric oxide and histaminergic pathways in pain inhibition by quercetin in mice. 85 male mice were randomly evaluated in 5 experimental phases with four groups and 5 repetitions in each group. In experiment 1, in order to investigate the analgesic effects of quercetin, the first group as a control, the second to fourth groups received levels of 50, 100 and 150 mg/kg of quercetin, respectively, and the fifth group received morphine (5 mg/kg). After determining the effective level of quercetin, the experiments of the second to fourth stages were designed and implemented. In the second experiment, experimental groups included control, injection of quercetin (150 mg/kg), naloxone (non-selective antagonist of opioid receptors, 2 mg/kg) and combined administration of quercetin (150 mg/kg) with naloxone (2 mg/kg). In third and fourth experiments, L-NAME (nitric oxide synthesis inhibitor, 10 mg/kg) and cyproheptadine (non-selective antagonist of histamine receptors, 4 mg/kg) were used instead of naloxone. Then the formalin test was performed by injecting it into the sole of the right foot and the duration of pain (time of licking and biting the injected foot) was measured in time periods of 0-5 minutes (first phase) and 15-30 minutes (second phase). According to the results, injection of different levels of quercetin significantly reduced pain time (P<0.05). Co-injection of naloxone or L-NAME plus quercetin significantly reduced the analgesic effects of quercetin (P<0.05). The results showed that quercetin has analgesic properties and this effect is mediated through the nitrergic and opioidergic pathways in mice. Manuscript profile
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  2 - Effects of Silymarin in Experimental Inflammatory Pain Induced by Formalin and Relation with Histaminergic System
  Mitra Gholizade Nikpey1 Ali Mojtahedin Reza Seyedsharifi
  Inroduction & Objective: The most common pain complaint of patients is one of the oldest forms of human problems.According to the therapeutic effects of medicinal plants,the effects of silymarin, an active ingredient of the Milk thistle, in an experimental model of infl More

  Inroduction & Objective: The most common pain complaint of patients is one of the oldest forms of human problems.According to the therapeutic effects of medicinal plants,the effects of silymarin, an active ingredient of the Milk thistle, in an experimental model of inflammatory pain induced by formalin and examined its relationship with the histaminergic system.Material and Methods:In this study, 42 male Wistar rats were used.Animals were divided into 7 groups in  each group 6 rats as follows: Group 1(Control): Normal Saline (i.p)+Formalin 1% (intraplantar), Group 2,3,4 and 5 Silymarin (50,100,200 and 400mg/kg, ip) respectively + Formalin 1%, Group 6: Ranitidine (20mg/kg, i.p) + Formalin 1%, Group 7: Ranitidine (20mg/kg, i.p) + Silymarin (200mg/kg, i.p) + Formalin 1%.Results: The results showed that intraplantar injection of formalin 1% significantly (PConclusion:The results revealed that silymarin produced antinociception effect in formalin induced pain and this effect probably will be down by interfering with the H2 histamine receptors. Manuscript profile