List of Articles Imipramine

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  1 - Preparation of cyclodextrin functionalized graphene nanosheets and its application in electrochemical determination of imipramine
  Hossein Dastyar Elham Tavana Farshid Fasihi Seyed Esmaeil Moradi Fatemeh Farjami
  In the present study, a glassy carbon electrode (GCE) modified with cyclodextrin graphene organic-inorganic hybrid nanosheets (CD-GNs) was prepared and applied for the sensitive electrochemical determination of imipramine (IMP). The surface morphology of the proposed el More

  In the present study, a glassy carbon electrode (GCE) modified with cyclodextrin graphene organic-inorganic hybrid nanosheets (CD-GNs) was prepared and applied for the sensitive electrochemical determination of imipramine (IMP). The surface morphology of the proposed electrode was characterized by scanning electron microscopy. Electrochemical results clearly demonstrated that CD-GNs organic-inorganic hybrid nanosheets could exhibit very high supramolecular recognition and enrichment capability. The effect of experimental conditions such as pH and scan rate were also investigated. Using differential pulse voltammetry (DPV), the modified electrode was applied for the sensitive determination of IMP in the range of 0.24-25 µM at pH 7.0. The limit of detection (S/N=3) was 47 nM. The RSD was obtained 1.75% which demonstrated the good repeatability of the fabricated electrode for IMP determination. Cyclic voltammetry (CV) was also used to attain information about the oxidation mechanism and calculating kinetic parameters. The proposed nanocomposite electrode exhibits good applicability for monitoring IMP in pharmaceutical formulations. Manuscript profile
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  2 - The Tratogenic Effect of Antidepressant Drug, Imipramine Hydrochloride on the Embryos of NMRI Mice
  عبدالحسین شیروی زهرا توپال
  Imipramine hydrochloride is an antidepressant drug used widely for the treatment of depression and anxiety. Action is via inhibition of uptake of serotonin and nor epinephrine at presynaptic nerve terminals. Several malformations in human, mainly neural tube defects, re More

  Imipramine hydrochloride is an antidepressant drug used widely for the treatment of depression and anxiety. Action is via inhibition of uptake of serotonin and nor epinephrine at presynaptic nerve terminals. Several malformations in human, mainly neural tube defects, reduction growth, increase of embryo resorbtion and increase of seizure and mother death. Results show that with increase of dose mean crown – rump and weight of the fetuses in three experimental groups were significantly reduced compared with those of the control groups. Furthermore mean of embryo resorbtion were significantly increase compared with control group. Manuscript profile