List of Articles Hydro Alcoholic Extract

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  1 - Effects of Hydro alcoholic Extract of Ferulago angulataon Glucose, Lipid Profile and Liver enzymes in Male Rats on High-fat Diet
  Maryamsadaat moshashaei somayeh bohlouli
  Inroduction & Objective: The use of herbal supplements to prevent and stop obesity is cheaper than chemical and synthetic drugs and has fewer side effects. in this study, the effect of Ferulago angulatahydro alcoholic extract on the biochemical parameters of male ra More

  Inroduction & Objective: The use of herbal supplements to prevent and stop obesity is cheaper than chemical and synthetic drugs and has fewer side effects. in this study, the effect of Ferulago angulatahydro alcoholic extract on the biochemical parameters of male rats on a high-fat diet was surveyed. Material and Method: Thirty-two male Wistar rats,which were randomly tested,were experimentally studiedin four groups: One control groupreceiving a fatty diet without extract;threeexperimental groups receiving Ferulago angulata extract of with doses of 50, 100 and 200 mg/kg. Nursing was performed for 20 weeks. At the end of the experiment, biochemical factors were tested on serum levels, including: glucose, triglycerides, cholesterol (HDL and LDL), leptin, and liver enzymes (ALT, AST, and ALP). Results: Doses of 50, 100 and 200 mg/kg of the extract reduced some biochemical and liver factors in rats compared to the control group under high-fat diet and the extract reduced cholesterol and leptin significantly. Different doses of choy extract significantly reduced the levels of leptin, glucose, triglycerides and liver enzymes (ALP / AST / ALT). LDL levels decreased. HDL levels also increased and cholesterol levels did not change Conclusion: In this study, the reducing effects of biochemical factors were observed at doses of 50, 100 and 200 mg/kg of extract, which may be evidenced by the positive effects of the extract of this plant on reducing harmful fats in the biochemical factors of the blood and the weight of the rats. Daily consumption of low dose of theextract of this plant can lead to fat metabolism and weight loss. Manuscript profile
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  2 - Berberis vulgaris Effects on Prefrontal Cortex of Male Wistar Rat After Global Transient Ischemia/Reperfusion
  Sara Babran Shabnam Movassaghi Mohammad Mahdi Nazarnejad Zahra Nadia Sharifi
  10.30495/jdb.2021.686360
  Background: Cerebral ischemia is a major global problem that can lead to the loss of cortical pyramidal cells following ischemic / reperfusion injury. Recent studies have examined the neuroprotective role of barberry hydroalcoholic extract in acute ischemia.Methods: Thi More

  Background: Cerebral ischemia is a major global problem that can lead to the loss of cortical pyramidal cells following ischemic / reperfusion injury. Recent studies have examined the neuroprotective role of barberry hydroalcoholic extract in acute ischemia.Methods: This study was performed experimentally on 18 male Wistar rats. Rats were divided into 3 groups of control ، ischemic and experimental. The ischemic model was performed by bilateral ligation of the common carotid arteries for 20 minutes and then blood was restored. In the experimental group, barberry hydroalcoholic extract was injected intraperitoneally for 7 days before ischemia. After 4 days of ischemia, the rat’s brains were removed and stained by applying chrysalis fast violet method. The number of pyramidal cells of the prefrontal cortex of all three groups was counted by Imaging-Pro-Plus software. Then, statistical analysis of the data was performed by one-way ANOVA and Tukey test.Results: The results showed that 20 minutes of ischemia significantly reduced the number of pyramidal cells in the cerebral cortex, so that there was a significant difference in the number of these cells between the ischemic group and the control and experimental groups. However, this difference between the control group and the experimental group was not significant.Conclusion: This study reveals that hydro alcoholic extract of barberry has a neurotropic effect on the pyramidal cells of the prefrontal cortex and can be considered as a new candidate for treating of ischemic brain injuries. Manuscript profile
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  3 - Effect of Black Radish Hydroalcoholic Extract on Kidney and Functional Kidney in Balb/c Mice
  Maryam Karimi Dehkordi Iman Jafari Guzel Rahbar Munira Shafahi Forough Mohammadi
  10.22034/ascij.2023.1961079.1397
  This study was performed to evaluate the effect of hydroalcoholic extract of black radish (Raphanus sativua) on complete blood cell count and kidney function in mice. Forty white mice were divided into four equal groups. Mice in the control group received only saline so More

  This study was performed to evaluate the effect of hydroalcoholic extract of black radish (Raphanus sativua) on complete blood cell count and kidney function in mice. Forty white mice were divided into four equal groups. Mice in the control group received only saline solution and mice in the second to fourth groups received 50, 100 and 150 mg/kg body weight of black radish plant extract, respectively, by intraperitoneal injection. After a 21-day trial period, blood samples were taken from the heart to count complete blood cells (hematocrit, hemoglobin, red and white blood cells) and urea nitrogen and creatinine in serum were measured. The results showed that treatment with black radish extract in any of the studied doses did not cause a significant change in blood cell count and nitrogen urea and creatinine (p < 0.05). These results were confirmed by histopathological examination of the kidney. Treatment of mice with horseradish extract resulted in a non-significant decrease in blood urea nitrogen and creatinine compared to the control group. Also, with increasing the dose of the extract, the amount of urea nitrogen and creatinine in each group decreased compared to the previous group, although this decrease was not significant (p < 0.05). The results of the present study indicate the extract in the doses used in the study, is not nephrotoxic and it can be said that under physiological conditions, the use of hydroalcoholic extract of radish not only has no toxic effect on the kidney in high doses, but also has positive effects on kidney function. Manuscript profile