List of Articles Heparin

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  1 - Evaluation of direct medical and non-medical costs of Unfractionated Heparin and Low Molecular Weight Heparin in Hospitalized Patients with Stroke due to Atrial Fibrillation
  Jamshid Bahmei nahid Hatam afshin Borhani Haghighi farnia Feiz reihane Sedghi Khosro Keshavarz
  Introduction: Diagnosis and treatment of patients with stroke spent high expenses annually. The aim of this study is to evaluate the direct medical and non-medical costs of stroke patients of Nemazee hospital. Methods: This study is a descriptive, cross-sectional analys More

  Introduction: Diagnosis and treatment of patients with stroke spent high expenses annually. The aim of this study is to evaluate the direct medical and non-medical costs of stroke patients of Nemazee hospital. Methods: This study is a descriptive, cross-sectional analysis that from April to July 2015 Namazi Hospital in Shiraz. The study population in this studies all patients with stroke in atrial fibrillation patients who have been treated with drugs or heparin clexan. The sample size was 80 and data were collected by questionnaire form and through interview. sampling was stratified sampling. Data were analyzed with using SPSS 18 software and descriptive statistics, t-test and one-way ANOVA test. Results: Average direct medical costs, direct non-medical costsand indirects costs of unfractionated heparinwere: 27,340,000±10,010,000 Rials, 3,862,750 ± 2,851,490 Rials and 5,382,500 ± 4,934,950 Rials respectively. Same averagedirect medical costs, direct non-medical costsand indirects costs of low molecular weight heparin were: 24,664,250±14,649,890 Rials, 2,233,500±4,249,590 Rials and 2,572,500±2,625,310 Rials respectively. Conclusion: Clexane drug compared to heparin treatment option with less total cost on the prevention of stroke in patients. The results of this study can also help patients to specialists and neurologists who can clexane of drug use in the treatment of lower cost. Introduction: Diagnosis and treatment of patients with stroke spent high expenses annually. The aim of this study is to evaluate the direct medical and non-medical costs of stroke patients of Nemazee hospital.Methods: This study was a descriptive-analytic study that was done cross- sectional in Shiraz hospital Nemazee in 2015. Research society for study included all of hospitalized stroke patients due to atrial fibrillation, which were treated with unfractionated heparin and low molecular weight heparin. The sample size was 80 and data were collected by questionnaire form and through interview. Sampling was stratified sampling. Data were analyzed with using SPSS 18 software and descriptive statistics, t-test and one-way ANOVA test.Results: Mean direct medical costs, direct non-medical costs and indirects costs of unfractionated heparin were: 27,340,000±10,010,000 Rials, 3,862,750 ± 2,851,490 Rials and 5,382,500 ± 4,934,950 Rials respectively. Also mean direct medical costs, direct non-medical costs and indirects costs of low molecular weight heparin were: 24,664,250±14,649,890 Rials, 2,233,500±4,249,590 Rials and 2,572,500±2,625,310 Rials respectively.Conclusion: costs less than unfractionated heparin for the prevention of stroke in patients. So the results of this research can be remarked as a case study to proof lower costs of low molecular weight heparin for patients treatment and help neurology specialists to select the more acurate drug to decrease treatment costs. Manuscript profile
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  2 - Evaluating the Potential of Polycaprolactone/Heparinized Nano Fluoro Hydroxyapatite Composite Scaffolds for Advancing Bone Tissue Engineering: A Comprehensive Analysis of Biodegradability and Water Absorption
  Nila Haghani Nahid Hasanzadeh Nemati Mohammad Taghi Khorasani Shahin Bonakdar
  The primary purpose of this study is to produce a composite scaffold using polycaprolactone (PCL) and heparinized nano-fluorohydroxyapatite for cancellous bone tissue engineering. The research investigated the impact of heparinized nano-fluorohydroxyapatite particles on More

  The primary purpose of this study is to produce a composite scaffold using polycaprolactone (PCL) and heparinized nano-fluorohydroxyapatite for cancellous bone tissue engineering. The research investigated the impact of heparinized nano-fluorohydroxyapatite particles on various properties of the scaffold, including water absorption, biodegradability, and alkaline phosphatase activity. The scaffold was produced using the phase separation (solid-liquid) method in combination with freeze-drying, and two different concentrations of heparinized nano-fluorohydroxyapatite powder were utilized. Biodegradability was assessed by submerging the scaffolds in phosphate-buffered saline for 6 weeks, showing that increased nano-fluorohydroxyapatite content enhanced biodegradability. PCL/10%w(H-nFHA50) exhibited the highest biodegradability rate. Water absorption analysis revealed that PCL scaffolds had lower water absorption compared to composite samples with heparinized nano-fluorohydroxyapatite, with PCL/10%(H-nFHA50) demonstrating the highest water absorption. Alkaline phosphatase activity was assessed on day 14 of cell culture, showing higher activity in heparinized samples compared to heparin-free samples in the presence of nano-fluorohydroxyapatite. The presence of heparin and nano-fluorohydroxyapatite in the scaffold structure likely contributed to this difference. No significant difference was observed between heparinized scaffolds with different nano-fluorohydroxyapatite concentrations. The results emphasize that the constructed scaffolds possess the potential for utilization in cancellous bone tissue engineering. Manuscript profile
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  3 - Preparation and evaluation of physical and cellular activity properties of poly (L-lactic acid)/ heparinized multiwall carbon nanotube nanocomposite films for application in nerve regeneration
  Shokoufeh Mounesi Rad محمد تقی خراسانی Morteza Daliri Joupari
  The objective of this study was to prepare crystalline poly (L-lactic acid) (PLLA)/multiwall carbon nanotube (MWCNT) nanocomposite films using solvent vaporization method, for nerve regeneration applications. Ultrasonic energy and heparinization of MWCNTs were used in o More

  The objective of this study was to prepare crystalline poly (L-lactic acid) (PLLA)/multiwall carbon nanotube (MWCNT) nanocomposite films using solvent vaporization method, for nerve regeneration applications. Ultrasonic energy and heparinization of MWCNTs were used in order to effective dispersion of the carbon nanotube in the PLLA matrix. The effect of fundamental system parameters including carbon nanotube types and concentrations on morphology of the films was studied by Scanning Electron Microscopy (SEM). Transmission Electron Microscopy (TEM) was carried out for characterization of nanotubes’ dispersion in PLLA. Contact angle and zeta potential measurements were used to investigate the hydrophilicity and negative surface charge of the films. In vitro studies were also conducted by using murine P19 cell line as a suitable model system to analyze neuronal differentiation over a 2-week period. SEM and immunofluorescence staining were used to confirm the cells attachment and differentiation on the films. Obtained results indicate that films containing heparinized multiwall carbon nanotubes (HMWCNTs) were quite acceptable for nerve regeneration and enhanced the nerve cell differentiation and proliferation. Manuscript profile