List of Articles Caspase-8

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  1 - The effect of eight weeks of aerobic training on some apoptotic factors of elderly men
  Farzane Tleb Mohammadi bahram abedi Mojtaba Khansooz
  10.30495/pah.2023.1993580.1055
  Objective: Impairment in the secretion and function of insulin in different tissues of the body is the main cause of type 2 diabetes. The purpose of this study is to investigate the effect of intense intermittent exercise and thyme honey on GLUT4 gene expression in sole More

  Objective: Impairment in the secretion and function of insulin in different tissues of the body is the main cause of type 2 diabetes. The purpose of this study is to investigate the effect of intense intermittent exercise and thyme honey on GLUT4 gene expression in soleus muscle and insulin resistance index in male obese rats with It is type 2 diabetes.Materials and Methods: In this experimental study, 36 rats (5-8 weeks old, weighing 110±10 g) were randomly divided into 4 groups of diabetes, diabetes-exercise, diabetes-supplement and diabetes-exercise-supplement. To induce type 2 diabetes, STZ was injected intraperitoneally at a dose of 25 mg/kg. Intense interval training was performed for 5 sessions per week for 8 weeks. Thyme honey in the amount of 3 g/kg was gavage in the supplement groups for 5 days a week before training. After blood sampling and tissue sampling, GLUT4 gene expression of soleus muscle and insulin resistance index were measured for data analysis using ANOVA test. Bonferroni's one-sided and post hoc tests were used at a significance level of P<0.05.Findings: Insulin changes in exercise group, supplement and supplement exercise showed a significant increase (P<0.05), insulin resistance values in the supplement group increased significantly compared to the control group (P=0.001). But the changes of this index in the training group showed a significant decrease compared to the control group, supplement and supplement training group. (p≥0.001) The level of GLUT4 has increased significantly in the training group and the training-supplement group. (P<0.05) Glucose changes in the exercise group and the exercise-supplement group were associated with a significant decrease (P<0.05).Conclusion: In addition to the findings of this research, it seems that eight weeks of intermittent exercise alone and together with the consumption of thyme honey improves insulin resistance and increases GLUT4 gene expression in diabetic samples. Manuscript profile
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  2 - The Cytotoxic Effect of Nandrolone on Colon Cancer Cell Line and the Evaluation of the Caspase-3, 8 and 9 activity
  Aahra Aalaei Abdolhossein Shiravi Rahim Ahmadi Vida Hojati
  The studies indicated that sex steroid hormones affect the digestive system function and proliferation of the cancer cells in the cell and molecular level. This study examines the anti-proliferative effects of Nandrolone on colon cancer (HCT) cell line and evaluates the More

  The studies indicated that sex steroid hormones affect the digestive system function and proliferation of the cancer cells in the cell and molecular level. This study examines the anti-proliferative effects of Nandrolone on colon cancer (HCT) cell line and evaluates the activity of caspases of 3, 8, and 9. In this experimental study, HCT cells were divided into the control group (without treatment) and groups treated with 0.625, 1.25, 2.5, 5, and 10 mg/ml of Nandrolone. The cytotoxic effect of hormone was measured using MTT. The activity level of caspases 3, 8, and 9 were evaluated by the standard kit. The data were compared among the groups using one-way analysis of variance and t-test. HCT cell viability significantly decreased in the groups treated with 2.5, 5, and 10 mg/ml of Nandrolone compared to the control group (p < 0.001); However, caspase 3 and 9 (p < 0.001) and caspase 8 activity (p < 0.01) significantly increased. This study's findings showed that Nandrolone has a cytotoxic effect on colon cancer cells, and this effect is partly mediated by increasing the caspases of 3, 8, and 9 activities. Manuscript profile