List of Articles Anxiety-like Behavior

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  1 - Interactions between D1 Dopaminergic Systems Of Nucleus Accumbens Shell and Glutamatergic System Of Prelimbic on Anxiety- Like Behaviors Of Wistar Male Rats
  Hatam Ahmadi Parvin Rostami Mohammad Reza Zarrindast Mohammad Nasehi Homa Mohseni Kokhesfahani
  Inroduction and Objective:Nucleus accumbens(NAC), prefrontal cortex(PFC) dopaminergic and glutamatergic systems are involved in regulating anxiety- like behaviors, while NAc dopaminergic system activity is mediated by glutamatergic projections, via PFC.This study has in More

  Inroduction and Objective:Nucleus accumbens(NAC), prefrontal cortex(PFC) dopaminergic and glutamatergic systems are involved in regulating anxiety- like behaviors, while NAc dopaminergic system activity is mediated by glutamatergic projections, via PFC.This study has investigated the involvement of NAc shell D1 dopaminergic and prelimbic glutamatergic systems on anxiety- like behaviors.Material and Methods:Elevated plus-maze apparatus was employed to test parameters of anxiety-like behaviors After 5 days surgery of male Wistar rats in a stereotaxic frame ,Elevated plus-maze apparatus was employed for measuring parameters of anxiety-like behaviors due to intrabrain injection of drugsSKF38393(dopamine D1 receptor agonist)SCH23390(dopamine D1 receptor antagonistNMDA(receptor antagonist), D-AP7NMDA receptor antagonist on Wistar male rats.Results: Unilateral intra- prelimbic injection of NMDA (0.9 μg/μl), induced anxiolytic-like behaviors which has been blocked by D-AP7(NMDA receptor antagonist, 0.25, 0.5 and 1 μg/μl). Moreover, unilateral infusion of SKF38393 (dopamine D1 receptor agonist, 3 μg/μl) 0.25, 0.5 and 1μg/μl) into the left NAc shell induced anxiolytic-like behaviors which was blocked by SCH23390 (0.25μg/μl), while, SCH23390 (dopamine D1 receptor antagonistdid not so; Furthermore, intra-NAc shell administration of subthreshold dose of SKF38393 (1 μg/μl) potentiated the lower dose, whereas decreased the higher dose of intra-left prelimbic NMDA response. In addition, the subthreshold dose infusion of SCH23390 (0.25 μg/μl) into the left NAc shell, intra- prelimbic NMDA reduced induced anxiolytic-like behaviors. Conclusion: The results demonstrated a modulatory effect of NAC shell D1 dopaminergic system on anxiolytic-like response by injection in prelimbic NMDA. Manuscript profile
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  2 - Evaluation the Role of GABAA and GABAB Receptors in Anxiety-like Behaviors Caused by Lipopolysaccharides in the Dark and Light Box (LDB) Test in Male Mice
  Masoumeh Alishahi Maryam Bananej Jalal Solati Ramin Hajikhani Mostafa Ghaderic
  Thegabaergic system is considered as the anti-anxiety system in the brain. The aim of this study was to investigate the role of GABAA and GABAB receptors in anxiety-like behaviors caused by lipopolysaccharides in male mice. In this test,mice were injected with lipopolys More

  Thegabaergic system is considered as the anti-anxiety system in the brain. The aim of this study was to investigate the role of GABAA and GABAB receptors in anxiety-like behaviors caused by lipopolysaccharides in male mice. In this test,mice were injected with lipopolysaccharide (LPS) (0.2 mg/kg), then injected with either muscimol (0.05, 0.1 or 0.2 µg/mouse), bicuculline (0.25, 0.5 or1 µg/mouse), baclofen (1, 2 or 4 µg/mouse) or CGP (0.2, 0.4 or 0.8 µg/mouse) 2 hours later and received intraventricular Celebrex. Five minutes after intraventricular injection, a dark and light box test was performed. The results of this study showed that musimol significantly reduced anxiety-like behavior in the LDB test (p < 0.05). The results of this study showed that musimol significantly reduced anxiety-like behavior in the LDB test (p < 0.05). However, the administration of musimol and LPS did not significantly change the animal’s anxiety-like behavior (p ≥ 0.05). Different doses of bioculin and LPS significantly increased the anxiety-like behavior in the LDB test (p < 0.05). Baclofen and CGP alone and with LPS did not significantly change the animal’s anxiety-like behavior on the LDB test (p ≥ 0.05). Celebrex injection after LPS relieved the anxiety-like behavior caused by LPS injection. In general, it can be claimed that anxiety-like behaviors in animals receiving LPS may be due to inhibition of GABAA and GABAB receptors and increase in the level of inflammatory factors in brain tissue. Manuscript profile