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      • Open Access Article

        1 - Comparison of Serum Levels of Vitamin C, Vitamin E, Selenium and the Activity of Glutathione Peroxidase Enzyme in Horses Affected with Strangles and Healthy Horses
        Mohammadreza Valilou Sina Moghaddam Ali Hassanpour
        Strangles is a prevalent infectious and contagious disease among Equidae that is caused by Streptococcus equi subspecies equi. The present study was performed on patient and healthy horses to evaluate serum levels of vitamin C (vitamin C), vitamin E (vitamin E), seleniu More
        Strangles is a prevalent infectious and contagious disease among Equidae that is caused by Streptococcus equi subspecies equi. The present study was performed on patient and healthy horses to evaluate serum levels of vitamin C (vitamin C), vitamin E (vitamin E), selenium (Sel) and glutathione peroxidase (GPx). Clinical signs and bacterial culture confirmed sixty patient horses. To separate the serum, blood samples were taken from the jugular vein of the studied horses. Blood samples were also taken from 52 healthy horses with similar conditions (age, diet, etc.). Serum levels of Vit E, Vit C, Se and serum’s activity of GPx were measured in samples taken from healthy and patient horses. The mean serum concentration of vitamin E, selenium and serum glutathione peroxidase activity in patient horses were significantly reduced. A significant increase in the patient's hemoglobin concentration was observed. The study of the relationship between serum selenium and antioxidants (serum glutathione peroxidase activity, vitamin E and hemoglobin) showed that increasing serum selenium also increased the antioxidants studied. Serum antioxidant markers were significant in patient horses in all three cases. The final outcome is that in horses which infected to strangles antioxidants like selenium, glutathione peroxidase and vitamin E reduced and these antioxidant intakes for dealing with them this issue should be considered in treating these patients. Manuscript profile
      • Open Access Article

        2 - تاثیر ویتامین های E و B₂ ( ریبوفلاوین ) بر رشد، بازماندگی و فاکتورهای خونی و ایمنی ماهی کپور معمولی (Cyprinus carpio, Linnaeus 1785)
        سیده عاطفه شریف زاده حسین خارا شایان قبادی
      • Open Access Article

        3 - Alcoholic Extract of Vitex (Vitexagnus-castus) and vitamin E on Serum Level of Hepatic Enzymes, Glucose, Lipid Profile and Insulin in Adult Female Rats
        Z. Nejaty S.E. Hosseini
        Chronic hyperglycemias led to diabetes that was a metabolic disorder caused by a defect in insulin secretion or function with decreased serum levels of vitamin E and the liver damaged.Vitex plant traditionally wasused to treat many diseases. The present study aimed to i More
        Chronic hyperglycemias led to diabetes that was a metabolic disorder caused by a defect in insulin secretion or function with decreased serum levels of vitamin E and the liver damaged.Vitex plant traditionally wasused to treat many diseases. The present study aimed to investigate the effect of Vitex and vitamin-E on serum levels on some hepatic enzyam, glucose, and insulin , lipid profile and weight was performed in rats.Methods: In this study, 40 adult female rats weighing 220 to 250 g in the controls group, and the 3 experimental groups were studied.Each group consisted of 8 mice. The experimental groups 1 weredivided by received 40mg / kg extract of Vitex, empirical 2received 40 mg/kg extract of Vitexand 40mg / kgvitamin E, and empirical 3 received 40 mg/kg vitamin E.Prescription was administered for 14 days, at the end of the fourteenth day, phlebotomizing by inter-ventricular to mice were performed and then by diagnostic kits, serum levels, insulin hormone, glucose, enzymes ALP, ALT and AST was measured. The data by using ANOVA and Tukeytest was analyzed and evaluated. The results showed that ethanol extracts of Vitex and vitamin E have no effect on glucose levels, while significantly caused to decrease the cholesterol, triglycerides, LDL, ALP and AST enzymes, and then increased insulin and HDL.Conclusion:Vitex Extract and Vitamin E due to antioxidant properties led to increased insulin hormone and HDL levels and reduced cholesterol, triglycerides, LDL ALP, AST enzymes. Manuscript profile
      • Open Access Article

        4 - Comparison the Effects of Vitamin E and Propolis on Interleukin-5 and STAT1 Gene Expression in Wistar Rats with Non-alcoholic Fatty Liver Disease
        Saeede Baarforoush Maryam Bananaj Ramin Hajikhani Hengameh Alibeik
        Nonalcoholic fatty liver disease (NAFLD) is a growing health concern worldwide. Unfortunately, scientists have not succeeded in finding a suitable treatment method for this disease, and more research is needed. Studies have shown that treatment with antioxidants is effe More
        Nonalcoholic fatty liver disease (NAFLD) is a growing health concern worldwide. Unfortunately, scientists have not succeeded in finding a suitable treatment method for this disease, and more research is needed. Studies have shown that treatment with antioxidants is effective in this disease. In this study, the effect of two different antioxidants on NAFLD induced in male Wistar rats was evaluated. This study was conducted on 32 male Wistar rats weighing 200 grams, which were randomly divided into four groups of eight. Mice were fed by gavage with high-fat emulsion at the rate of 2 mg/kg for 40 days. After suffering from fatty liver, the level of interleukin-5 (IL-5) in the serum was measured and also the expression level of STAT1 gene was determined using real-time PCR. The results showed that the level of serum IL-5 in the patient group significantly increased compared to the control group, and the treatment groups with vitamin E and propolis, significantly decreased the level of interleukin-5 compared to the patient group (p < 0.05). In addition, the greatest decrease was related to the propolis group (p < 0.05). On the other hand, the level of STAT1 gene expression in the fatty liver group is significantly increased compared to the control group (p < 0.05); Whereas, after treatment with antioxidants, the expression of this gene decreased (p < 0.05). Based on the obtained results, the use of propolis and also vitamin E as natural antioxidants by reducing the inflammatory interleukin and also reducing the expression of genes effective in the formation of NAFLD, have a promising therapeutic role in non-alcoholic fatty liver disease. Manuscript profile