List of Articles نانوکوکومین

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  1 - Effect of Nano-curcumin on the Treatment of Non-alcoholic Fatty Liver Disease (NAFLD) in Hypercholesterolemia Mice
  Sahar Farzaneh Sepideh Farahinia
  According to the widespread use of nanoparticles in medicine, the pathological study seems to be necessary. Important properties of nanoparticles are their small size. Accumulation of fat and inflammation of the liver are the beginning stage of liver cirrhosis. We aimed More

  According to the widespread use of nanoparticles in medicine, the pathological study seems to be necessary. Important properties of nanoparticles are their small size. Accumulation of fat and inflammation of the liver are the beginning stage of liver cirrhosis. We aimed to determine the effect of nano-curcumin on fatty liver disease. Sixty male mice were divided into 6 groups (n=10): control, gavaged with normal food. The second group were fed cholesterol, third group were fed cholesterol and curcumin. Other groups were fed different dose of nano-curcumin. Then, lipid profile and liver enzymes were measured and liver tissues were fixed in formalin buffer, staining with hematoxylin-eosin. Data were analyzed using SPSS. Evaluation of serum cholesterol showed that treatment with curcumin significantly decreased cholesterol, TG, and LDL of plasma level. Histopathological changes of the liver in the group received cholesterol showed vacuoles of fat, in groups which were fed low doses of the nano-curcumin did not show fat vacuoles of fat. Nano-curcumin may be used in the safe doses for treatment of nonalcoholic fatty liver disease. Manuscript profile