مقاومت انسولین

Open Access Article

1 - Comparison of the Effect of Eight Weeks of Endurance Training at Morning and Evening on Asprosin, Leptin, Insulin Resistance and Appetite Index in Non-athlete Obese Men
bahman Zadeh-Hendijani sedigheh Hoseinpour Delavar mohammad karimi mehran ghahramani

10.22034/ascij.2023.1999845.1558

Satiety-hunger signals regulate rhythmic clocks in peripheral tissues through the availability of many macronutrients in the circulation. The aim of this research was to study the effect of eight weeks of endurance training in the morning and the evening on serum levels More

Satiety-hunger signals regulate rhythmic clocks in peripheral tissues through the availability of many macronutrients in the circulation. The aim of this research was to study the effect of eight weeks of endurance training in the morning and the evening on serum levels of asprosin, leptin, insulin, insulin resistance and appetite index in non-athlete obese men. In this semi-experimental study, 36 non-athletic obese young men with an average age of 25.4 ± 3.3 years, weight 98.3 ± 7.7 kg, and body mass index 31.8±1.2 kg/m2 were selected as subjects in a targeted and available manner. Subjects were randomly divided into three equal groups including; Control, morning training and evening training. The endurance training protocol was implemented for eight weeks, three sessions per week and with an intensity of 60 to 75% of the maximum heart rate. Before and after the training period, blood sampling was done at 10 hours of overnight fasting state. The data were analyzed using one-way analysis of variance and at a significance level of p < 0.05. Eight weeks of endurance training led to a significant decrease in asprosin (p = 0.0001), leptin (p = 0.02), insulin (p = 0.0001), glucose (p = 0.0001), insulin resistance (p = 0.0001) and appetite index (p = 0.001). Tukey’s post hoc test indicated that, compared to the control group, evening training has a greater and more significant effect on all the mentioned variables. It seems that endurance training in morning and evening can have positive effects on asprosin, leptin, insulin resistance and appetite index. However, training in the evening seems to have more positive effects on these factors. Manuscript profile

Open Access Article

2 - The effect of resistance training on the expression of cell adhesion molecules and RAGE in left ventricular of diabetes rats induced by high-fat diet and STZ
Mohammad Reza Bagheri Afsariehee Abdolali Banaeifar Sajad Arshadi Shahram Sohaeily

10.22034/ascij.2023.2000361.1559

Introduction: Diabetic cardiomyopathy (DCM) is a pathophysiological condition that occurs in response to diabetes and leads to heart failure. The purpose of this study was to the effect of resistance training on ICAM-1, VCAM-1 and RAGE gene expression in left ventricula More

Introduction: Diabetic cardiomyopathy (DCM) is a pathophysiological condition that occurs in response to diabetes and leads to heart failure. The purpose of this study was to the effect of resistance training on ICAM-1, VCAM-1 and RAGE gene expression in left ventricular in obese rats with type 2 diabetes.Materials & Methods: In this experimental study, 14 male Wistar (220 ± 10 g) diabetic rats induced by high fat diet and STZ injection were randomly divided into resistance or control groups. The training protocol was performed for 6 weeks in 5 sessions per week in the form of 3 sets with 5 repetitions in each set. Rest intervals between sets and repetitions in each set were 90 and 30 seconds, respectively. All rats were dissected 48 h after the last training session. The independent t-test was used to compare variables at a significance level of alpha less than 5 percent.Results: Resistance training did not lead to a significant change in the expression of ICAM-1 (P = 0.237), VCAM-1 (P = 0.295) and RAGE (P = 0.561) compared to the control group. However, it led to a significant decrease in glucose and insulin resistance and a significant increase in serum insulin (P = 0.001).Conclusion: Based on the findings of the present study, resistance training in the absence of changes in the expression of ICAM-1, VCAM-1 and RAGE in left ventricular is associated with the improvement of glycemic profile and insulin resistance in type 2 diabetic rats. Manuscript profile

Open Access Article