List of Articles سرطان رحم

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  1 - Effects of Cytotoxicity of Nanoparticles of Ag/Si_O_P /Gelatin on Uterus Cancer Cell Lines (Hela)
  سیده مبینا موسوی سروینه باغی عباسعلی دهپور جویباری صدف فرخنده
  Nowadays, cancer is the second cause of mortality in the world and among its variants; the most common cancer in women is the ovary cancer. One of the methods for cancer treatment is chemical therapy. Some nanoparticles can be considered as a sensitizer because they enh More

  Nowadays, cancer is the second cause of mortality in the world and among its variants; the most common cancer in women is the ovary cancer. One of the methods for cancer treatment is chemical therapy. Some nanoparticles can be considered as a sensitizer because they enhance the cytotoxicity due to oxidative stress and increase the free radicals, especially reactive oxygen species (ROS), within cells resulting in cell death. In this study, elevated synergistic effect of Ag/Si_O_P /gelatin nanoparticles as radiosensitizer was evaluated in presence of cobalt-60 gamma rays on human ovary cancer cell line. In this experimental and laboratories study ,after duplication and farming the Hela cell class, gelatin silver nanoparticles with10, 20, 40, 60, 80, 160 densities are effected by Hela cancer cells, and after 72 hours of using MTT, the cytotoxicity is evaluated and the data are analyzed by Elisa Reader and Anova. The Results shown that silver nanoparticles of (p≤5%) 20, 40, 80 density after 72hours, the cell growth is significantly decreased according to controlled group. Silver nanoparticles of different sizes and density of this study is shown that gelatinous nanoparticle have effective cell relation or cancer cell (Hela) and highly induced apoptosis in cells and caused the death of cancer cell and have the lower poisonous to natural body cells. Manuscript profile
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  2 - Effect of Lycium depressum Root on Bax , Bcl-2 Gene Expressions and Evaluation of Caspase 3 and 6 Activity on Uterine Cervical Cancer cells line (Hela)
  Yasamin Khani Tahereh Naji Soheila Zamanlui Benisi Saeid Mohamadi Motamed
  10.22034/ascij.2023.1979055.1463
  Cervical cancer is the third cause of death caused by cancer in women. After breast cancer, cervical cancer is the most common cancer in women. Today, due to the numerous side effects of chemotherapy and radiation therapy that are caused to the patient as a result of th More

  Cervical cancer is the third cause of death caused by cancer in women. After breast cancer, cervical cancer is the most common cancer in women. Today, due to the numerous side effects of chemotherapy and radiation therapy that are caused to the patient as a result of their use, as well as the resistance of cancer cells to common treatments, researchers have turned to new drugs with greater effectiveness and less toxicity. The aim of the present study was to evaluate the effect of Lycium depressum root on the expression of Bcl2 and Bax genes and to evaluate the activity of caspases 3 and 6 in cervical cancer cells (Hela). In this study, firstly, the extract of Lycium depressum root was obtained by soaking method, then cervical cancer cells were prepared and cultured, in order to calculate the optimal effective dose of the extract, the MTT technique was used. The concentrations of 25 and 50 mg/ml were chosen as optimal doses. Then the expression of Bcl2 and Bax genes was evaluated by Real-time PCR technique. Next, in order to evaluate the activity of caspases 3 and 6 in effective doses of the extract, cervical cancer cells (Hela) were affected and protein expression was measured using the immunocytochemistry (ICC) technique. The results of this research showed that the roots of the Turkmen oleander plant can cause changes in the expression of important Bcl2 and Bax genes in the path of apoptosis induction. In addition, it increases the protein expression of caspase 3 and 6 in cancer cells. Therefore, it can be hoped that in additional research on the extract of Lycium depressum root, it will be considered a candidate for the treatment of complementary medicine. Manuscript profile