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  1 - Synthesis of polymer-supported organic compounds for the preparation of amines, amino acids and peptides
  Maaroof Zarei Aliasghar Jarrahpour Abdolhamid Fadavi
  Trimellitic anhydride was attached to Merrifield resin and used in the synthesis of primary amines by reaction with HMDS and conversion of anhydride moiety to phthalimide group. The resin containing phthalimide group was also used in the preparation of amino carboxylic More

  Trimellitic anhydride was attached to Merrifield resin and used in the synthesis of primary amines by reaction with HMDS and conversion of anhydride moiety to phthalimide group. The resin containing phthalimide group was also used in the preparation of amino carboxylic acids. Preparation of tripeptide derived from glycine was conveniently performed by this method, too. All reactions were easily progressed and purification of products was performed using simple washing of resin without using column chromatography. The yield of products is good to excellent yield. Significantly, residual resin from reactions can be used again in the mentioned syntheses with its conversion to resin containing trimellitic anhydride. Based on the functional groups, infrared spectroscopy was used to monitoring ‎ progress of a reaction ‎and product formation. Purification using simple washing and filtering, avoidance of expensive and time-consuming separation techniques and sequential reactions are some advantages of present method. Manuscript profile