List of Articles اندنسترون و متوکلوپرامید

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  1 - مقایسه ی اثر اندانسترون و متوکلوپرامید در پیشگیری از تهوع و استفراغ بعد از عمل جراحی در بیماران بستری در بخش جراحی عمومی بیمارستان فارابی مشهد از سال 1386 تا سال 1387
  Behruz Hushmand Seyed Mohsen Ghasemi Fatemeh Seyedi khabaz
  BACKGROUND: Antiemetics currently in use are not totally effective.Serotonin receptor antagonists are a new class of antiemeticsthat have shown promise for treatment of nausea andvomiting in many situations. This study evaluates the efficacy of the Serotonin receptor an More

  BACKGROUND: Antiemetics currently in use are not totally effective.Serotonin receptor antagonists are a new class of antiemeticsthat have shown promise for treatment of nausea andvomiting in many situations. This study evaluates the efficacy of the Serotonin receptor antagonist, ondansetron,for the prevention of postoperative nausea and vomiting. METHODS: This randomized, double-blind study compared the efficacy of an intravenous dose of ondansetron 4 mg with metoclopramide 10 mg for the prevention of postoperative nausea and vomiting (PONV) in patients undergoing general anesthesia for openabdominal surgery. A total of 126 patients (63 ondansetron, 63 metoclopramide), ASA status I–II, aged 18–65yr,were included and received study medication 30 minutes after the induction of anaesthesia and a standardized anesthetic technique and intraoperative analgesia were used in all patients. The proportion of patients experiencing emesis or nausea and the duration of nausea and the number of emetic episodes, were recorded during the 24-h period after surgery. RESULTS: During the overall observation period (0-24 h), significantly more patients who received ondansetron had no emetic episodes (87.3%) than those who received metoclopramide (73%, P = 0.044). A higher proportion of patients receiving ondansetron (71.4%) did not experience nausea (metoclopramide 63.5%, P=0.342). CONCLUSIONS: Ondansetron was superior to metoclopramide for preventionof vomiting in the first 24h after surgury and the total number of emetic episodes was reduced significantly compared with metoclopramide, but no significant differenceswere observed between ondansetron and metoclopramide for nauseacontrol or treatment failure.   Manuscript profile