List of Articles : Diabetes

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  1 - The effect of six weeks of aerobic exercise on the expression of genes involved in aortic tissue pyroptosis of healthy and diabetic male mice
  samira hasanpoor solimani asieh abbassi daloii Ahmad Abdi shirin zilaei bouri
  Inroduction & Objective: In diabetes, inflammatory processes play a key role and affect all the complications of diabetes. Inflammation is associated with the caspase-1 process, which activates the anti-inflammatory cytokines IL-1β and IL-18, leading to the dea More

  Inroduction & Objective: In diabetes, inflammatory processes play a key role and affect all the complications of diabetes. Inflammation is associated with the caspase-1 process, which activates the anti-inflammatory cytokines IL-1β and IL-18, leading to the death of inflammatory proteins, which is one of the occurrences of pyroptosis. The aim of this study was to investigate the effect of six weeks of aerobic exercise on the expression of genes involved in aortic tissue apoptosis in healthy and diabetic mice. Materials and Methods: For this purpose, forty male rats (8 weeks old) were divided into 4 groups (10 in each group) after familiarization with exercise protocol: 1) control-healthy, 2) control-diabetes, 3) exercise-diabetes, and 4) exercise. -Healthy. Diabetes model was first induced, then run for 5 days on treadmill for 6 weeks. After 12 to 14 hours of fasting and 72 hours after the last training session, aortic tissue sampling was performed for IL-1β, IL-18, NLRP3 and Caspase-1 analysis by Real Time PCR technique. Data analysis was performed using one-way ANOVA, if significant difference was seen by Tukey post hoc test to determine the difference between groups (P <0.05). Results: Induction of diabetes led to a significant increase in IL-1β, IL-18, NLRP3 and Caspase-1 genes expression in rat aorta, which resulted in a significant decrease in aerobic exercise. Also, aerobic exercise in healthy mice also decreased the expression of IL-1β, IL-18, NLRP3 and Caspase-1 gene in aortic tissue. Conclusion: Aerobic exercise may be used as an effective non-pharmacological method to improve diabetes-induced inflammation and prevent vascular disorders. Manuscript profile
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  2 - The effect of oil extract of Portulaca oleracea seeds on insulin resistance indices in mice
  Ali Kargary Rezapour Rana Vatandoust
  Recently, drugs of natural origin have been considered for treatment of diabetes. Purslane (Portulaca oleracea) is an important endemic Iranian medicinal plant. The aim of this study was to investigate the effect of oil extract of purslane seeds on insulin resistance in More

  Recently, drugs of natural origin have been considered for treatment of diabetes. Purslane (Portulaca oleracea) is an important endemic Iranian medicinal plant. The aim of this study was to investigate the effect of oil extract of purslane seeds on insulin resistance indices in mice. In this study 30 adult mice were divided into five groups of six: (1) Negative control (non- diabetic), (2) positive control (diabetic), (3) purslane seeds extract control (non-diabetic), (4) 150 (mg/kg) oil extract of purslane seeds (diabetic) and (5) 300 (mg/kg) oil extract of purslane seeds (diabetic). Pursulane extract was gavaged to groups 3, 4 and 5 for one month. After this period, diabetes induction was performed by injection of streptozocin in 2nd, 4th and 5th groups. After two months, blood samples were taken and the indices were measured and analyzed statistically. The overall period of the study was 3 months. Oil extract of purslane seeds decreased serum glucose significantly in diabetic groups in comparison to positive diabetic group (p<0.05). The levels of serum insulin were also increased in the 3rd, 4th and 5th groups (p<0.05). However, no significant differences were seen in lipid profile, HOMA-IR, QUICKI and atherogenic index. The results indicated that pursulane seeds decreased serum glucose in diabetic mice and it had insulinogogic effect.   Manuscript profile