The Effect of Tilia platyphyllos extract on Varicocele-Induced Testicular Sperm Parameters in Adult Male Wistar Rats
Subject Areas : animal physiologyreyhaneh mohebali 1 , Akram Eidi 2 , pejman Mortazavi 3 , mohamad amin edalatmanesh 4
1 - Department of Biology, College of Sciences, Shiraz Branch, Islamic Azad University, Shiraz, Iran
2 - Science and Research Branch
3 - Department of Pathobiology, Faculty of Specialized Veterinary Science, Science and Research Branch, Islamic Azad University, Tehran, Iran
4 - Department of Biology, College of Sciences, Shiraz Branch, Islamic Azad University, Shiraz, Iran
Keywords: Testis, Rat, Varicocele, Tilia platyphyllos, Linden,
Abstract :
AbstractThe reproductive system of men with varicocele is affected by the negative effects of oxidative stress on the testicles. In traditional medicine, the linden (Tilia platyphyllos L.) is used as a medicine to treat stomach ulcers, spasms and sedatives. Chemical compounds such as terpenoids and flavonoids have been identified in the linden. The aim of this study was to evaluate the effect of linden extract on testicular pathology of healthy and varicocele rats. In this study, 48 rats were randomly divided into 8 groups: Healthy control, healthy groups receiving linden extract (50, 100 and 200 mg / kg intragastrically, daily) alone, Infertile control (varicocele surgery), varicocele groups together with linden extract (50, 100 and 200 mg / kg intragastrically, daily). After 60 days, sperm analysis was performed and data were analyzed using one-way analysis of variance.Our results showed that sperm analysis was significantly decreased in infertile control animals compared to the normal control group. linden treatment prevented sperm changes and caused a significant increase in sperm parameters of infertile animals and decreased varicocele damage and protected the natural structure of the testis. Our results suggest that linden acts as a potent antioxidant against varicocele-induced damage in the rat.
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