Association study of polymorphisms rs3761548 in FOXP3 gene and Migraine disease

Subject Areas : genetics

Leila Solgi ¹ , Sedigheh Farahani ² , شهره زارع کاریزی ³

1 - Department of Biology, Varamin-Pishva branch, Islamic Azad University, Varamin-Iran
2 - Department of Biology, Varamin-Pishva branch, Islamic Azad University, Varamin-Iran
3 -

Received: 2020-03-22 Accepted : 2020-05-05 Published : 2019-05-22

Keywords: migraine, polymorphisms, rs3761548, FOXP3 gene, regulatory T cells,

Abstract :

Background: FOXP3 is required for the generation and function of regulatory T (Treg) cells. The gene is involved in regulation of inflammatory responses and neuronal cell development. Migraine is an inflammatory disease and is considered as a polygenic multifactorial disease, and it seems that many genes are involved in this disease. The aim of the present study is to determine if any relation exists between foxp3 rs3761548 gene polymorphisms on the individual susceptibility of migraine. Materials and methods: In this study, 148 patients with clinically definite migraine and 149 ethnically-matched healthy controls participated. Genotyping was performed using PCR-RFLP method for the mentioned polymorphisms in the FOXP3 gene. Logistic regression test were used for estimating odd ration and 95% CI by using SPSS ver.16 software. Results: No significant difference in distribution of foxp3 rs3761548 alleles and genotypes was found in females and males with a history of migraine in comparison to control (p=0.08). Conclusion: This is the first report concerning the association between foxp3 gene polymorphisms and migraine. The further study of FOXP3 related pathways and gene networks might result in the better understanding of the pathophysiology of migraine and related symptoms.