Echocardiographic study of changes on the Mitral E- point septal separation distance in dog after administration of Propofol
Subject Areas : Journal of Large Animal Clinical Science Research(JLACSR)
Keywords: Dog, Ultrasonography, Propofol, Echocardiography, E point,
Abstract :
One of the primary principles in surgery is suitable and safe anesthesia with minimum side effects. Many drugs are used for this purpose. Propofol is a suitable drug for anesthesia in dogs. This drug, of course, can have effects on some of body parameters, the matter that should be controlled according to the sick subject. In this study, 10 male mixed adult dogs with about 20- 25kg weight were selected. The miteral valve of the dogs was surveyed by ultrasonography machine and their M-mode miteral value echocardiogram was registered. Then the distance of E point to the wall between ventricles was measured. After preparation of M-mode miteral value echocardiography, the animals were anaesthetized by propofol with suggestive dose of 6 mg/kg through vein. M-mode echocardiography changes of miteral valve booked immediately after venous injection until the animal regained its consciousness. Then recorded changes of echocardiograms at especial times were transformed into computer pictures. Also the distance of E point to the septum in the same way was measured. Changes in the distance of E point to septum of M-mode valve echocardiography after and before injection were compared. In this study, the mean of distance in control animal was 5.36 0.23 millimeters and the mean of distance in anaesthetized animals was 6.00 0.20 millimeters which showed significant difference between them (P<0.05). And also this study indicated that Propofol can affect this distance.
1- Baudoulas, F., Wooley, C., Mitral Valve, (2000): 4th, Futura, New York, pp: 70-80,219-257, 560-585.
2- Bettina, G., Anderson, Wesly, D., Anderson, (1994): Atlas of Canine Anatomy, Anderson and Anderson, Lea & Febiger londone, Tok Awarerly Company, pp: 315-382.
3- Cartee, R.B., (2000): an Atlas and Textbook of Diagnostic Ultrasonography of the Dog and Cat, First Edition, Manson publishing, pp: 68-112.
4- Dyce, K. M., Sack,W.D.,Wensing C.J.G., (1996): Textbook of veterinary Anatomy, Saunders company, Philadelphia, pp: 213-225, 399-407.
5- Faletra, F., La Marchesina, U., Bragato, R., Grimaldi, A., , (2002): Mitral insufficiency, Ital Heart J Suppl, May; 3(5): 486-94.
6- Filipovic, M., Wang, J., Michaux, I., Hunziker, P., Skarvan, K., Seeberger MD., (2005): Effects of halothane, sevoflurane and propofol on left ventricular diastolic function in humans during spontaneous and mechanical ventilation, Br J Anaesth, Feb; 94(2): 186-92.
7- Gare, M., Parail, A., Milosavljevic, D., Kersten, J.R., Warltier, D.C., Pagel, P.S., (2001): Conscious sedation with midazolam or propofol does not alter left ventricular diastolic performance in patients with preexisting diastolic dysfunction: a transmitral and tissue Doppler transthoracic echocardiography study, Anesth AnalgOct; 93 (4): 865-71.
8- Gooddar, P. J., (1995): Veterinary ultrasonography, CABinternational, pp:1-12, 131-160.
9- Green, R, W., (1996): Small Animal ultrasonnd, lipincott- Ravin, Philadelphia, pp: 305-319.
10- Hall , L. W., Clarke , K. W., Trim C. M., (2003): Veterinary Anesthesia , 10th, W.B. Saunders , London, pp: 123-5.
11- Kealy, M. A., Allister, M. C., (2000): Diagnostic radiology and ultrasonography of the Dog and Cat, Mosby year book, Philadelphia, pp: 106-162.
12- Labovits, A.J., Williams, G.A., (1992): Doppler Echocardio grophy, 3th, Lea and Febiger, Philadelphia, PP: 61-78.
13- Lburk, R., Afeency, D., (2003): Small animal Radiology and-ultrasound, 3th, Saunders, pp: 45–55.
14- Miller, R.D., (2000): Anesthesia, 5th, Churchill livingstone Philadelphia, PP: 249-256.
15- Nyland, T., Mattoon, J., (2002): veterinary Diagnostic ultrasound, Saunders, Philadelphia, PP: 198-230.
16- Otto, C., (1999): Valvular heart Disease, Saunders, Philadelphia, pp: 218-229-296-320.
17- Reef, V.B., (1991): Advance in Echocardiography, Vet Clinics of North America, Equ.practice, 4:126-140.
18- Skarda, R.T., Hubbell, J.A., Muir, W.W., Bednarski, R.M., Mason, D.E., (1996): Sedation and anesthesia in dogs and cats with cardiovascular diseases, Ventilation, respiratory monitoring, treatment for postoperative pain, Schweiz Arch Tierheilkd, 138(6):312-8.
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