Compare the therapeutic effect of honey on cutaneous leishmaniasis in the laboratory and human by Glucantim

Subject Areas : Journal of Large Animal Clinical Science Research(JLACSR)

Received: 2021-08-04 Accepted : 2021-08-04 Published : 2011-03-21

Keywords: Honey, Glucantime, Cautaneous Leishmaniasis, Salak,

Abstract :

Cautaneous Leishmaniasis show different form of clinical sign, the wound getting larger gradually and plague wound at the end will appear at the bite site. Long term treatment, drug resistance, delay in healing, treatment with chemical drug, there side effect, painful, high cost medication are the main reason of this research in comparison with Glucantime. Number of 30 mice with samples of Leishmania prepared infected and to determine the incidence of ulcers, they in the environment of cultured NNN and RPMI. Following’s a culture we have. Of the 30 samples 20 samples treated with honey, 10 samples were selected as controls. By the legal permission and application forms prepared from before, 24 patients, preparing biopsy and culture test (NNN) from there wound, divided in 2 groups, a group (treatment with honey) and B (treatment with glucantime) were under   study. Total 30 samples of animals with wounds treated with Leishmania and extract them to count the number 8 for 18 days; 16 days and 5 number 7 number average length of 22 days and recovered in 18-19 days. Diameter 4/0-3/0 mm ulcer rate was reduced daily. 10 control samples number 3 and the rest died within 70 days showed partial improvement. Wound healing  of the patient in group A show more affective in comparison with chemical drug ,the healing period of honey on the leishmaniasis infection of 9 patient average time were between 23 to 25 days and in 3 others patient of this group were between 34 to 38 days, In group B healing period of the wound of 7 patient were between 160 to 180 days and 5 other patient of this group there wound heal after 220-230 day. The other founding, regarding the control of diameter of the wound in the patient those person how had used honey there wound diameter extension were stop much more sooner than those patients had chemical drug. The honey (combinational of drug) used in this study can be suitable replacer drug against chemical drug treatment. Also the honey able to improve scar of Salak.

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