Studying of Propofol’s effects-induced general anesthesia on biochemical changes of serum in domestic hen
Subject Areas : Journal of Large Animal Clinical Science Research(JLACSR)
Keywords: Biochemical parameters, Propofol, general anesthesia, Domestic Hen,
Abstract :
Propofol is a short-acting intravenous general anesthetic for induction and maintenance of general anesthesia. Propofol used alone or in combination with other CNS depressant drugs in human and animals. Nowadays studies considering usage of anesthetic drugs in poultries for research and surgery purpose are in developing. Injectable drugs have problems in poultry, so inhalant anesthetic drugs are preferred. But sometimes inhalant anesthetic drugs have problems too. In this experimental study, we evaluate serum biochemical change subsequent propofol-induced general anesthesia in adult aborigine hen. Therefore 10 adult aborigine hens selected randomly. To induce anesthesia propofol (7.5mg/kg) injected intravenously and for maintenance propofol (0.5mg/kg/min) infused until 90 minute with infusion pump. During anesthesia the following biochemical factors were determined in 0, 15, 30, 60, 90 minutes and 24, 72 hours after anesthesia. Serum albumin, alanine amino transferase (ALT), aspartate amino transferase (AST), alkaline phosphates (ALP), bilirubin, blood urea nitrogen (BUN) and creatinine concentration were measured. Results showed that: bilirubin, BUN, ALP and creatinine concentrations significantly changed (p<0.05), but ALT, AST and albumin concentration had none significantly changed. Using this drug in poultry’s anesthesia and surgery needs to be investigated more.
1- Bayan, H., Sarma, K.K., Chakravarty, P. (2002): Biochemical and hematological change during propofol anesthesia in canine. Indian Journal of Veterinary Surgery, 23(2):95-96.
2- Gunkel, C., Lafortune, M. (2005): Current techniques in avian anesthesia. Seminars in Avian and Exotic Pet Medicine, 14(4):236-276.
3- Hall, L.W., Chambers, J.P. (1987): A Clinical trial of propofol infusion anesthesia in dogs. Journal of Small Animal Practice, 28:623-637.
4- Hall, L.W., Clark, K.W., and Trim, C.M. (2001): Veterinary anesthesia, 10th Edition, W.B. Sunders, pp: 113-130.
5- Jens, S., Neil, A.F. (2003): The effects of isoflurane anaesthesia on some doppler-derived cardiac parameters in the common buzzard (Buteo buteo). The Veterinary Journal, 166:273-276.
6- Kamiloglu, A., Atalan, G., Kamiloglu, N.N. (2008): Comparison of intraosseous and intramuscular drug administration for induction of anesthesia in domestic pigeons. Research in Veterinary Science, 85:171-175.
7- Kwon, Y., Jang, K., Kim, J.E., Chae, H., Lim, J.H., Lee, K.W., Jang, I.H. (1999): Effects of Continuous administration of propofol in dogs. Korean Journal of Veterinary Clinical Medicine, 16(2): 363-368.
8- Lorsomradee, S., Cromheecke, S., Lorsomradee, S., De hart, S. (2006): Effects of sevoflurane on biochemical of hepatic and renal dysfunction after coronary artery surgery. Journal of cardiovascular and vascular anesthesia, 20:684-690.
9- Lukasik, V.M., Gentez, E.J., Erb, H.N. (1997): Cardiopulmonary effects of propofol anesthesia in chickens (Gallus gallus). J Avian Med Surg, 11(2):93-97.
10- Machin, K.L., Caulkett, N.A. (1998): Cardiopulmonary effects of propofol and medetomidine-midazolam-ketamine combination in mallard ducks. Are J Vet Res, 59(5):598-602.
11- Mama, K.R., Phillips, L.G. Jr., Pascoe, P.J. (1996): Use of propofol for induction and maintenance of anesthesia in a barn owl (Tyto Alba) undergoing tracheal resection. J Zoo Wildlife Med, 27(3):397-401.
12- Martin, P.H., Murthy, B.V.S., Petros, A.J. (1997): Metabolic, biochemical and haemodynamic effects of infusion of propofol for long-term sedation of children undergoing intensive care. British journal of anesthesia, 79:276-279.
13- Mitchell, M.A., Sandercock, D.A., Hunter, R.R., Carlisle, A.J. (1999): Skeletal muscle damage following halothane anaesthesia in the domestic fowl: plasma biochemical responses. Research in Veterinary Science, 67:59-64.
14- Murphy, J.P., Fialkowski, J. (2001): Injectable anesthesia and analgesia of birds. Available at: www.ivis.org.
15- Nevarez, J.G. (2005): Monitoring during avian and exotic pet anesthesia. Seminars in Avian and Exotic Pet Medicine, 14(4):277-283.
16- Paige, C.N., Ikuko, T., Stephanie, A.W. (2005): Caudal thoracic air sac cannulation in zebra finches for isoflurane anesthesia. Journal of Neuroscience Methods, 143:107-115.
17- Short, C.E., Bufalari, A. (1999): Propofol Anesthesia, Veterinary Clinical of North America. Small Animal Practice, 29:737-778.
18- Wang, Y.L., Yao, S.L., Shang, Y. (2004): Protective effects of propofol in the hepatic ischemic-reperfusion injury during normothermic partial hepatectomy. Anesthesia and analgesia journal, 98(1):282.
19- Watkins, S.B., Hall, L.W., Clarke, K.W. (1987): Propofol as an intravenous anesthesia agent in dogs. Veterinary Record, 120:326-329.
20- Weaver, B.M.Q., Raptopoulos, D. (1990): Induction of anesthesia in doges and cats with propofol. Veterianry Record, 126:917-620.
21- Wolf, A., Weir, P., Segar, P., Stone, J., and Shield, J. (2001): Impaired fatty acid oxidation in propofol infusion syndrome. The lancet, 357:606-607.
_||_