Antioxidant and Antiapoptotic Effect of Resveratrol in Diabetic Rats

Subject Areas : Journal of Large Animal Clinical Science Research(JLACSR)

Received: 2021-08-15 Accepted : 2021-08-15 Published : 2013-09-23

Keywords: Antioxidant, Rat, Resveratrol, Diabetes,

Abstract :

       Antioxidant and Antiapoptotic Effect of Resveratrol in Streptozotocin Induced Diabetic Rats. Oxidative stress is strongly associated with development and the complications of diabetes. In the present study, we have investigated the effect of resveratrol on antioxidants status in streptozotocin induced diabetic rats.48 male wistar rats with were randomly assigned into four equal groups namely healthy control vehicle treated group (normal saline), healthy group received resveratrol (5 mg/kg), diabetic control group and diabetic group treated with resveratrol (5 mg/kg).  The experimental rats were treated in related groups for 16 weeks and at the end of experiment the level of malonaldehyde (MDA) and anti-oxidant enzymes activity including superoxide dismutase (SOD), glutathione peroxidase (GPx) and catalase (CAT) were measured in red blood cells. Significant differences among the groups were determined by one-way analysis of variance followed by Bonferroni post-test. Statistical significance was considered (p< 0.05). Diabetic rats showed significant increase in the value of MDA and a decrease in the activities of SOD, GPx and CAT of red blood cells (p<0.001). Oral administration of resveratrol resulted in significant reduction in the level of MDA and significant increase in the activities of SOD, GPx and CAT of red blood cells (p<0.001). Diabetic rats showed significant increase in apoptotic cells and Oral administration of resveratrol resulted in significant reduction testicular apoptosis in diabetic rats. The results of this study provide confirmatory evidence of oxidative stress and testicular apoptosis in diabetes and show the anti-oxidative and antiapoptotic effect of resveratrol.

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