Histopathological study of morphine use before pregnancy on kidney of rat neonatal

Subject Areas : Journal of Large Animal Clinical Science Research(JLACSR)

Received: 2021-07-11 Accepted : 2021-07-11 Published : 2010-03-21

Keywords: kidney, Morphine, Histopathologic, Rat neonatal,

Abstract :

Morphine is the main substance of opium. It is in a group of drugs called opoid like. This drug is used to treat moderate to sever pain. Morphine is highly potent opiate analgesic drug. It is also a natural endocrine product in humans and animals. Objective is histopathological study of morphine effect on kidney in rat neonatal. The aim of this investigation was histopathological study of morphine effects on kidney in Rat neonatal. In this study 40 wistar rats (20 male and 20 female), aged 8 weeks and weighted 250±10 gr were used. Female rats were divided into two groups, experimental (N=10) and control (N=10). Experimental groups received morphine (4mg/kg, IM, Daily) for 30 days. Control groups received normal saline (1cc, IM, Daily) for 30 days. Then female rats (experimental and control groups) were caged with male rats.  After parturation, biopsy was taken from kidney tissue of neonatal rat from both groups. Then sampels were prepared for LM studies. Microscopic observarion demonstrated intercellular fossa in proximal and distal tube layer, Glomerular hialinization, Dilation of proximal and distal tube and existance urate in proximal and distal tube. This study showed that morphine can reach the fetus via the placenta and cause renal failur in neonatal rat. 

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