The effect of caloric restriction on reserpine-induced catalepsy in rats model of Parkinson's disease
Subject Areas : zoology
Azam
Khalaj
1
(Department of Physiology, faculty of science, qom Branch, Islamic Azad University, qom, Iran)
Tahreh sadat
Shobeiri
2
(Department of Physiology, faculty of science, qom Branch, Islamic Azad University, qom, Iran)
Mohammad Reza
Yazdian
3
(Department of medicine, faculty of science, qom branch, Islamic azad university, qom, Iran)
Keywords: catalepsy, Parkinson', s disease, caloric restriction, Rat,
Abstract :
Aim and Background: Parkinson's disease is the second most common neurodegenerative disorder after Alzheimer's disease and the most common cause of disability . it is a progressive disease that is associated with the destruction of nerve cells. Caloric restriction is the only preventive action that has a life long-lasting effect on laboratory models. It has been shown in a large scale of laboratory animals that caloric restriction increases life expectancy, decreases the incidence of several age-related diseases, and preserves youth activities. Therefore, the aim of this study was to investigate the effect of caloric restriction diet on reserpine-induced catalepsy in male rats model of Parkinson's disease. Material and Methods: In this study, 30 Wistar rats were divided in 5 groups (control, Parkinson's disease,caloric restriction, Parkinson's disease + caloric restriction, caloric restriction+ Parkinson's disease(2) ).Animals in caloric restriction groups were under the caloric restriction of 30 percent. Parkinson's disease was induced by administration of Reserpine (1 mg/kg, i.p). The bar- test was used to measure cataleptic symptoms. Results: catalepsy was significantly lower in of caloric restriction + Parkinson's disease and caloric restriction+ Parkinson's disease (2) groups than in Parkinson's disease group. (P <0/05). Conclusion: caloric restriction of 30 percent can improve reserpine-induced catalepsy in male rats model of Parkinson's disease. Also, caloric restriction before inducing Parkinson's disease reduces the severity of complications after getting sick, including catalepsy.
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