Effect of Hydroalcholic Extract 0f Trachyspermum Copticum on Anxiety in Male Rats
Subject Areas : zoologyZohreh Mohammadi manesh 1 , Nasrin Heidarieh 2 , Mohammad Moghadami rad 3
1 - Department of Biology, Qom Branch, Islamic Azad University, Qom , Iran
2 - Department of Biology, Qom Branch, Islamic Azad University, Qom , Iran
3 - Department of Biology, Qom Branch, Islamic Azad University, Qom , Iran
Keywords: Anxiety, hydroalcholic extract, Trachyspermum copticum, elevated plus maze, Male rats,
Abstract :
Anxiety is a common disorder of unknown origin associated with an unpleasant feeling .According to the anxiolytic effects Trachyspermum Copticum traditional medicine , trachyspermum Copticum effect on anxiety male Wistar rats were investigated. trachyspermum. copticum seed after detection by the University Herbarium, hydro-alcoholic extract was extracted by Soxhlet and the extract powder was prepared using smart legitimate. In this study, male Wistar rats (230 ± 20 g) were placed In groups intact, recipient of the DMSO (solvent extraction) (0.3 cc), received obtained in different doses of 50, 25, 15 mg/kg. All injections were performed intraperitoneally. Half an hour after injection, anxiety was measured using the elevated plus maze. Indicators of anxiety for 5 minutes, including time spent and number of entries into the open arm was recorded. Data were analyzed by ANOVA statistical tests and Tukey test (p <0.05) .The results showed that the group receiving the extract solvent (DMSO) compared to intact in time spent and number of entries into the open arm does not show a significant difference. The group receiving a dose 15 mg/kg compared to the group receiving DMSO in time spent and number of entries into the open arm showed a significant increase. C. copticum hydro-alcoholic extract anxiolytic effects in low doses.
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