Eeffect of the hydroalcolic Lavandula stoechas L. extract in Comparison Glibenclamide on blood glucose in streptozotocin induced diabetic male rats

Subject Areas : zoology

zahra abolghasemi ¹ , ramesh ahmadi ² , maryam khoshsokhan ³

1 - Master degree of Islamic Azad University, Iran, Qom, Qom
2 - Assistant Professorof Biology, Faculty of Science, Islamic Azad University, Iran ,Qom ,Qom
3 - Assistant Professorof Biology, Faculty of Science, Islamic Azad University, Iran ,Qom ,Qom

Received: 2016-11-02 Accepted : 2017-01-24 Published : 2017-05-22

Keywords: lavender, glibenclamide, Diabetes, Rats,

Abstract :

Introduction: The aim of this study was to determine the effect of plant extracts of lavender in Comparison libenclamide in reducing blood sugar levels on instreptozotocin–induced diabetic male Wistar rats. Material and Methods: In this study, 48 Wistar rats were divided in 8 groups (n=8). Diabetes was induced by single injection of streptozotocin (55 mg/kg, i.p) Lavender extract at a dose of 200 mg/kg were gavage to rats during the 21 days. In this study the effect of Lavender was compared with glibenclamide. SPSS software was used for analyzing data by using of analysis of variance and tukey's test. Results: The results indicate that there is a significant difference between blood sugar levels in group of rats treated with the extract after gavage period compared to group treated with glibenclamide (at a dose of 0/5 mg / kg) dissolved in DMSO or saline. Conclusion: Lavender was decreased blood glucose in streptozotocin-induced diabetic animals that it probably can be because of Lavender's important compounds such as linalool, butyric acid, propionic acid, valeric and gerambol. The linalool that presents in this plant, decreased blood sugar levels by increasing insulin levels. Anti-hyperglycemic effect of linalool is because of stimulating and activating insulin receptors in the cells.