The Effects of IP Injection of Fe2NiO4 Nanoparticles on Serum TSH,Thyroid Hormone (T4, T3) and Thyroid HistologyRunning Title: Effect Fe2Nio4 on TSH, T3, T4 in Rat
Subject Areas :Hosna Fallahi 1 , Zahra Houshmandi 2
1 - کارشناسی ارشد بیوشیمی، گروه زیست شناسی، واحد سنندج، دانشگاه آزاد اسلامی، سنندج. ایران.
2 - استادیار دانشکده علوم پایه، گروه زیست شناسی، واحد سنندج ، دانشگاه آزاد اسلامی، سنندج. ایران
Keywords: T4, T3, TSH, Keywords: Fe2NiO4,
Abstract :
Inroduction & Objective:The increased production and use of nanoparticles has led to the growing concerns about their negative side effects on biological systems. This study evaluated the effect of Fe2NiO4 nanoparticle on the serum levels of TSH, thyroid hormones (T3, T4) and thyroid histology.Methodsand materialMale Wistar rats were randomly divided into 3 groups: Control: rats received 0.5 ml saline for 7 consecutive days. Group 1 and 2: rats received 0.5 ml of nanoparticle solution at doses of 100 and 200 ppm. Serum biochemical parameters were evaluated in rats, after 2, 7 and 14-days of post exposure. On the 14th days thyroid tissue was removed and used for histological assessment.ResultsOn the 7th and 14th days, the serum levels of TSH in rats exposed to nanoparticle were significantly lower than that in the control group. IP injection of Fe2NiO4 had no effects on serum T3 level but significantly increased serum level of T4. Fe2NiO4 caused significant alterations in thyroid histology.ConclusionFe2NiO4 nanoparticles can disrupt synthesis and secretion of T4 and TSH through alteration of Hypothalamic-pituitary- endocrine axis and damage of thyroid tissue