Effect of high intensity interval training and Eryngium billardieri consumption on adipose visceral Lipocalin2 gene and insulin resistance in rats with metabolic syndrome

Subject Areas : Physical Activity and Health

Azadeh Sadat  Pour Hashemi ¹ (Master in exercise physiology, Department of physical education & sport sciences, East Tehran Branch, Islamic Azad University, Tehran, Iran.)
Shahin  Riyahi Malayeri ² (Assistant Professor exercise physiology, Department of physical education & sport sciences, East Tehran Branch, Islamic Azad University, Tehran, Iran,)
Arezoo  Kalhor ³ (Master in exercise physiology, Department of physical education & sport sciences, East Tehran Branch, Islamic Azad University, Tehran, Iran)
Farzane  Salavattizadeh ⁴ (Master in exercise physiology, Department of physical education & sport sciences, East Tehran Branch, Islamic Azad University, Tehran, Iran)

Received: 2022-03-16 Accepted : 2022-06-17 Published : 2022-06-22

Keywords:

Abstract :

Lipocalin 2 is a new adipokine that is secreted from adipose tissue and is closely related to mild inflammation, obesity and metabolic syndrome. The aim of this study was to investigate the effect of high intensity interval training (HIIT) and hornbill consumption on the expression of visceral fat lipocalin 2 gene in rats with metabolic syndrome. In this experimental study, 32 rats were randomly divided into four groups (healthy control, metabolic syndrome, metabolic syndrome + humpback, metabolic syndrome + humpback + exercise). The HIIT training program was performed for 8 weeks, 5 sessions per week with an intensity of 80-95% of the maximum speed. Groups receiving daily supplementation received 50 mg of borage extract per kilogram of body weight gavage for 8 weeks. Visceral fat lipocalin 2 gene expression was measured by real-time PCR. Data were analyzed using one-way analysis of variance. The results showed that eight weeks of HIIT training with hornet consumption significantly reduced lipocalin 2, blood glucose, serum insulin and insulin resistance index in rats with metabolic syndrome (P <0.05). It seems that eight weeks of HIIT training combined with the consumption of hornbeam with a reduction in visceral fat lipocalin 2 can be effective in improving the metabolic syndrome.

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