The effect of aerobic training on serum levels of Brain-derived neurotrophic factor (BDNF) and interleukin-6 (IL-6) in middle-aged obese men
Subject Areas : New studies in exercise metabolism and physical activity
Alireza reyhani
1
,
Ali Yaghoubi
2
*
1 - Department of Physical Education and Sport Science, Bojnourd Branch, Islamic Azad University, Bojnourd, Iran
2 - Department of Sport Science, Bojnourd Branch, Islamic Azad University, Bojnourd, Iran
Keywords: Aerobic training, IL-6, BDNF, Obese men,
Abstract :
Obesity is associated with increased probability of central nervous system disorders. Therefore, the aim of the current research was the effect of aerobic exercise on the level of brain-derived nerve growth factor (BDNF) and interleukin-6 (IL-6) in the serum of obese middle-aged men. For this purpose, 20 obese middle-aged men (35-45 years old and BMI>30) were randomly assigned to two groups of aerobic training and control. Aerobic training was performed 3 sessions a week with an intensity of 80% of the reserve heart rate and 30 minutes in each session. Serum BDNF and IL-6 levels were measured by ELISA method. Paired t-test and independent t-test were used for intra-group and inter-group comparisons. The results showed that BMI, PBF and IL-6 level were significantly lower in the post-test of the aerobic training group compared to the pre-test (p<0.05). The level of BDNF increased in the post-test of the aerobic group compared to the pre-test, but it was not statistically significant (p=0.093). Overall, these results show the positive effects of aerobic exercise on BMI, PBF and serum IL-6 levels in obese middle-aged men, but despite the increase in serum BDNF levels in these subjects, this increase was not statistically significant. It seems that traininf intensity was not sufficient to increase BDNF level in line with improvement of systemic inflammation.
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