Fabrication and Evaluation of Morphological, Structural and Biocompatibility Properties of Chitosan Nanofibrous Scaffolds Coated with ZIF-8 Metal-organic Framework for Application in Wound Dressing
Subject Areas :
1 - Department of Textile Engineering, Yazd University, Yazd, Iran
Keywords: Nanofibrous scaffold, chitosan, metal-organic framework, in-situ synthesis, biocompatibility.,
Abstract :
In this study, chitosan-based nanofibrous scaffold was produced for application in wound dressing by electrospinning method. Then, the zinc-based metal-organic framework (ZIF-8) was in situ synthesized method on nanofibrous scaffold. The effect of growth time of ZIF-8 crystals on chitosan nanofibrous scaffolds was studied in order to achieve a uniform and continuous coating. The morphology and structure of the produced scaffolds were evaluated using scanning electron microscopy (SEM), X-ray diffraction (XRD) and Fourier transform infrared spectroscopy (FTIR). In order to evaluate the potential of fabricated scaffolds in wound dressing, surface wettability, antibacterial activity, biocompatibility and cell viability were also investigated. The electron microscope images showed that after 30 minutes, ZIF-8 nanoparticles grew with a relatively uniform distribution with an average size of 80 nm on the chitosan scaffold. The results showed that the scaffolds were biocompatible after 24 hours of cell culture and also had antibacterial properties against Gram-negative and Gram-positive Escherichia coli and Staphylococcus aureus, respectively. Due to the appropriate structural and morphological properties as well as the appropriate biocompatibility and antibacterial performance of the nanofibrous scaffold coated with a metal-organic framework, it can be used as a suitable candidate in wound dressing applications.
[1] B. Hadavi Moghadam, M. Hasanzadeh, A.K. Haghi, Bulgarian Chemical Communications, 45, 2013, 169.
[2] B. Maddah, H. Chamani, M. Hasanzadeh, Journal of Chemical Health Risks, 7, 2017, 299.
[3] A. Abedi, M. Hasanzadeh, L. Tayebi, Materials Chemistry and Physics, 237, 2019, 121882.
[4] Y. Gutha, J.L. Pathak, W. Zhang, Y. Zhang, X. Jiao, International Journal of Biological Macromolecules, 103, 2017, 234.
[5] A. Hamedi, A. Anceschi, F. Trotta, M. Hasanzadeh, Journal of Inclusion Phenomena and Macrocyclic Chemistry, 99, 2021, 245.
[6] M. Hasanzadeh, A. Simchi, H.S. Far, Materials Chemistry and Physics, 233, 2019, 267.
[7] H. Shahriyari Far, M. Hasanzadeh, M. Najafi, T. Masale Nezhad, M. Rabbani, Industrial & Engineering Chemistry Research, 60, 2021, 4332.
[8] X. Zhu, J. Tong, L. Zhu, D. Pan, International Journal of Biological Macromolecules, 205, 2022, 473.
[9] M. Hasanzadeh, F. Tajdar, Advanced Materials and Novel Coatings, 10, 2021, 2690.
[10] R. Gil-San-Millan, E. Lopez-Maya, M. Hall, N.M. Padial, G.W. Peterson, J.B. DeCoste, L.M. Rodriguez-Albelo, J.E. Oltra, E. Barea, J.A.R. Navarro, ACS Applied Materials & Interfaces, 9, 2017, 23967.
[11] G. Wyszogrodzka, B. Marszałek, B. Gil, P. Dorozynski, Drug Discovery Today, 21, 2016, 1009.
[12] Z. Ansari-Asl, S. Darvish Pour-Mogahi, E. Darabpour, Applied Nanoscience, 115, 2021, 1.
[13] B.H. Moghadam, M. Hasanzadeh, A. Simchi, ACS Applied Nano Materials, 3, 2020, 8742.
[14] C. Wang, T. Zheng, R. Luo, C. Liu, M. Zhang, J. Li, X. Sun, J. Shen, W. Han, L. Wang, ACS Applied Materials & Interfaces, 10, 2018, 24164.
[15] Y. Zhang, Y. Zhang, X. Wang, J. Yu, B. Ding, ACS Applied Materials & Interfaces, 10, 2018, 34802.
[16] J. Yang, A. Hui, W. Wang, F. Yang, Y. Kang, A. Wang, International Journal of Biological Macromolecules, 189, 2021, 698.
[17] I. Kohsari, Z. Shariatinia, S.M. Pourmortazavi, International Journal of Biological Macromolecules, 91, 2016, 778.
[18] N. Ahmad, N.A. Nordin, J. Jaafar, N.A. Malek, A.F. Ismail, M.N.F. Yahy, S.A.M. Hanim, M.S. Abdullah, Particuology, 49, 2020, 24.
[19] C.Y. Sun, C. Qin, X.L. Wang, G.S. Yang, K.Z. Shao, Y.Q Lan, Z.M Su, P. Huang, C.G. Wang, E.B Wang, Dalton Transactions, 41, 2012, 6906.
[20] H.N. Abdelhamid, M. Dowaidar, Microporous and Mesoporous Materials, 300, 2020, 110173.
[21] A. Mazloom-Jalali, Z. Shariatinia, I.A. Tamai, S.R. Pakzad, J. Malakootikhah, International Journal of Biological Macromolecules, 153, 2020, 421.
[22] V. Hoseinpour, Z. Shariatinia, Tissue Cell, 72, 2021, 101588.
[23] C. Liu, Y. Wu, C. Morlay, Y. Gu, B. Gebremariam, X. Yuan, F. Li, ACS Applied Materials & Interfaces, 8, 2016, 2552.
[24] N.M. Mahmoodi, A. Taghizadeh, M. Taghizadeh, Carbohydrate Polymer, 227, 2020, 115364.
[25] J.L. Whittaker, S. Subianto, N.K. Dutta, N.R. Choudhury, Polymer (Guildf), 87, 2016, 194.
[26] W. Xu, Y. Chen, J. Kang, B. Li, Journal of the Iranian Chemical Society, 16, 2019, 385.
[27] Y. Xu, Y. Fang, Y. Ou, L. Yan, Q. Chen, C. Sun, J. Chen, ACS Sustainable Chemistry & Engineering, 8, 2020, 18915.