lncRNAs in multiple sclerosis disease
Subject Areas : Molecular genetics of microorganismsNasrin Nasiri Kelishadi 1 * , Zahra Zamanzadeh 2 , Aida Mahdipour 3 , Aryan Mahdipour 4
1 - Department of Biology, Faculty of Basic Sciences, Shahrekord Branch, Islamic Azad University, Shahrekord, Iran
2 - Department of Biotechnology, Faculty of Biological Sciences and Technology, Shahid Ashrafi Isfahani University, Esfahan, Iran
3 - Department of Experimental Sciences, Isfahan University, Isfahan, Iran
4 - Department of Dentistry, Faculty of Dentistry,Pedia Trichisky University, St. Petersburg, Russia
Keywords: lncRNA, autoimmune disease, multiple sclerosis, biomarker,
Abstract :
Multiple sclerosis is a chronic inflammatory and Autoimmune disease of the CNS, which is associated with axon demyelination and disruption of nerve signaling. MS is a multifactorial disease caused by the interaction of environment, genetics and epigenetic factors. Among the effective epigenetic factors in this field are types of ncRNAs that are effective in regulating gene expression. lncRNAs are long non-coding RNAs that are more than 200 nucleotides long and play an important role in regulating gene expression. More than half of lncRNAs are expressed in the cells of the central nervous system, their expression is important in the development and function of the nervous system. They are involved in the development of different parts of the brain, the differentiation of oligodendrocytes and myelination. It has also been found, the abnormal expression of lncRNAs by regulating gene expression and cooperation in biological processes has a significant impact on the pathogenesis and progression of immune system diseases like MS and plays an important role in regulating the function of immunology. In the present review study, a review of articles on the effect of lncRNAs on MS shows that lncRNAs like HOTAIR, NEAT1, TUG6, ENST00000491934.2, HSP90AA4P, XR-132575.3, lnc DC are effective in MS, GAS5, UC.341, RN7SK, PANDA, THRIL, ENSG00000231898.3, XLOC-009626, XLOC-010881, TOB1-AS1 and linc_MAF-4 with increased expression and PVT1, FAS- AS1, ENSG00000233392.1, ENSG00000259906.1 and XLOC-010931 are associated with decreased expression in patients compared to healthy individuals, and UCA1 and CCAT2 are associated with expression differences between diseased and healthy women over 40. Abnormal expression of lncRNAs is effective in the pathogenesis and progression of MS, and it is hoped that by studying them, new therapeutic approaches and biomarkers for early diagnosis and evaluation of treatments and the course of the disease will be provided.
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