Comparison of the histopathological effects of acepromazine and xylazine as preanesthetic drug on the kidney in pigeon
Subject Areas : HistologyReza Osolzadeh 1 , masoud soltani 2 * , Behnam Pedram 3 , Melina Daghighian 4
1 - department of veterinary medicine
2 - Veterinary Department, Faculty of Agriculture, Shoushtar Branch, Islamic Azad University, Shoushtar, Iran
3 - Pathology Departemant, Azad Islamic University, Sosangerd, Iran
4 - Doctor of Veterinary Medicine Student, Faculty of Veterinary Medicine, Islamic Azad University, Shushtar Branch, Shushtar, Iran.
Keywords: histopathology, ketamine acepromazine xylazine, pigeon,
Abstract :
The goal of performing this research wa. So, we used 18 completely healthy male pigeons in the age range 8 to 12 months and their weight was between 300 to 450 g. The first group considered as the witness group and they were injected 30 mg/kg ketamine. And the second group were injected 1 mg/kg acepromazine intramuscularly and after 10 minutes, they were injected 30 mg/kg ketamine. The third group were injected 5 mg/kg xylazine and 10 minutes after that, they were injected 30 mg/kg ketamine. 24 hours after the injections, tissue samples were taken frome the pigeons' kidney and histopathological reviews were performed. Microscopic examinations showed no damage in the kidney tissues in the witness group. In the second group's kidneys we witnessed mild hyperemia, mononuclear infiltration in kidney interstitium, necrosis and severe damage in epithelial tubular cells and also destruction of intercellular adhesion and separating cells from tubular basement membrane. The third group's kidneys were without necrosis but there were mild hyperemia in arteriols and mononuclear infiltration in kidney interstitium in small amounts and there was a mild degeneration in some of proximal convulated tubules. The three groups' livers showed a normal situation but we witnessed a mild hyperemia in the second group and a mild mononuclear infiltration in kidney interstitum in the second and third group around the portal. The results of this research, for the first time showed that a prescription of acepromazine-ketamine for anesthesia in pigeons will cause severe tubular damage in kidneys