Tubular carcinoma of the mammary gland in a Guinea pig: A case report

Subject Areas : clinical veterinary science

Diba Golchin ^{1 *}

1 -

Received: 2024-12-30 Accepted : 2025-03-10 Published : 2025-04-10

Keywords: Guinea pig, Mammary gland tumor, Tubular carcinoma, Histopathology,

Abstract :

Spontaneous neoplasms in guinea pigs are uncommon. Compared to dogs and cats, the most popular pets, less data is available regarding predisposing factors for neoplasia in this species. A 4.5-year-old female guinea pig suffering from a mammary gland tumor died after five days of anorexia, being irresponsive to therapeutic interventions, and was subjected to necropsy. Tubular carcinoma of the mammary gland, lacking lymphovascular invasion, and mild vesicular degeneration of hepatocytes in the liver were the most significant histopathological findings. Previously, various types of mammary adenocarcinomas, including one case of tubular carcinoma, have been reported in guinea pigs. Papillary bronchogenic adenoma is the most frequently reported neoplasm in guinea pigs, followed by neoplasms of the skin and subcutaneous tissue. To date, no standardized system has been developed for grading the malignancy of mammary tumors in guinea pigs, and histologic classification of these tumors is greatly based on canine and feline algorithms.

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