Evaluation of healing effects of Leoheal spray(Allantoin, Boric acid, CH and Carbomer) on rats with full thickness excisional wound

Subject Areas : clinical veterinary science

Amin Nikpasand ^{1 *} , seyede fatemeh Azariyan ² , Majid Mohammadsadegh ³

1 - Department of clinical sciences, Karaj branch, Islamic Azad University, Karaj, Iran
2 -
3 - Department of clinical sciences, Garmsar branch, Islamic Azad University, Garmsar, Iran

Received: 2025-01-07 Accepted : 2025-03-11 Published : 2025-04-10

Keywords: Leoheal spray, allantoin, wound healing, carbomer, boric acid,

Abstract :

Wound healing is a dynamic and complex process that includes 4 phases of hemostasis, inflammation, proliferation and matrix remodeling and is supported by a large number of cellular events. Leoheal spray contains the active ingrediants of allantoin, carbomer, boric acid and chlorhexidine. According to the severity and extent of the wound, the duration of treatment and treatment methods will be different. The use of topical ointments, new dressings and biological coatings are used to treat the wound. One of the other ways to repair wounds is to use chemical compounds that are effective in repairing skin layers. The combination of these materials with a synergistic effect in performance can also be effective in repairing it according to the nature of the damage. The purpose of this research to study the effectiveness of leoheal spray on the quality of wound healing process. This study was conducted on 20 male rats with an average weight of 250 to 300 grams. Rats were divided in two groups of without drug and positive control, and according to Abramov's indices, the effectiveness of drug on wound healing was evaluated using Shapro and Yelk statistical tests. The results of the statistical analysis showed that our desired indicators collagen deposition, neovascularization, fibroblast maturation, acute and chronic inflammation and the formation of granulation tissue in the two groups had no significant difference and only in the process of re epithelization followed a positive trend. (P=0.4). Leoheal spray leads to the improvement of re epithelization process in resection wounds.

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