The study of Effects of aqueous extract of flaxseed on feta, placental and Hofbauer cell in BALB/c mice on days 3�6 of pregnancy
Subject Areas : clinical veterinary scienceنرجس Mirab 1 , پروین Torabzade 2 , منیره Movahedi 3
1 - karaj Branch, Islamic Azad University, Karaj, Iran
2 - Faculty of science, karaj Branch, Islamic Azad University, Karaj, Iran
3 - Faculty of science, karaj Branch, Islamic Azad University, Karaj, Iran
Keywords: flaxseed, hofbauer cell, placenta,
Abstract :
Flaxseed (Linum usitatissimum) is an example of the herbs that has been under investigation of including lignin,fber, α-linolenic acid (ALA), omega-3, phytoestrogen and suggested to be used for the treatment of menopausalhot flashes, depression, decrease blood glucose levels, blood lipids level. Since estrogen is one of the factorsin pregnancy and the normal concentration of this hormone during pregnancy is essential in the successfulcopletio. According to the high levels of phytoestrogens in flaxseed, the use of this plant in early pregnancy causesdisturbances. That’s why, the effect of aqueous extract of flaxseed on fetal weight, placental weight and the numberof hofbauer cell was determined.Nine groups of Balb/c, each includes ten adult females were selected. The experimental groups received(0.05،0.1،0.2،3.75،7.5،15، 21 mg/kg. b. w) of flaxseed. The control group received no medication, and the shamgroup received only distilled water. The samples were taken at 15 of gestation. Weight of Fetal, placental weightand the number of hofbauer cell measured and analyzed as well. The results were analyzed by Duncan, ANOVAand TUKY test between the control and experimental group. Weight of fetal and placenta in the experimentalgroups showed statistically signifcant decrease comparing with control group (P<0.05). Flaxseed probably causeddecreasing in developmental of fetal and placenta. The increasing number of hofbauer cell confrmed that flaxseedis an external factor.