Study of the effect of 3, 4 methylenedioxymeth amphetamine (MDMA, Ecstasy) on the serumic levels of urea, creatinine, total protein and albumin in the dog

Subject Areas : Veterinary Clinical Pathology

بهرام Amouoghli-Tabrizi ¹ , هادی Khayat-Nori ² , کمال Asadzade, K ³ , امین Zargarzade ⁴ , Gh Mousavi ⁵ , Ali Rezapour kargari ⁶ , مهرداد Neshat ⁷

1 - Department of Clinical Sciences, Faculty of Veterinary Medicine, Islamic Azad University, Tabriz Branch, Tabriz, Iran
2 - Department of Clinical Sciences, Faculty of Veterinary Medicine, Islamic Azad University, Tabriz Branch, Tabriz, Iran
3 - Graduate of Veterinary Medicine, Islamic Azad University, of Tabriz, Tabriz Branch, Tabriz, Iran
4 - Graduate of Veterinary Medicine, Islamic Azad University, of Tabriz, Tabriz Branch, Tabriz, Iran
5 - Department of Clinical Sciences, Faculty of Veterinary Medicine, Islamic Azad University, Tabriz Branch, Tabriz, Iran
6 - Department of Animal Sciences, Faculty of Agriculture, Islamic Azad University, Tabriz Branch, Tabriz, Iran
7 - Department of Clinical Sciences, Faculty of Veterinary Medicine, Islamic Azad University, Tabriz Branch, Tabriz, Iran

Received: 2008-07-18 Accepted : 2008-08-25 Published : 2008-05-21

Keywords: total protein, Urea, Ecstasy, albumin, Creatinine, Dog,

Abstract :

   In order to evaluate the effects of Ecstasy on the kidney function, five 3.5-4 years old male mixed breed dogs were selected. Blood and urine samples were collected and recorded as time zero or control samples before drag administration. Then each dog was given Ecstasy tablets orally at a single dose of 150 mg/kg and blood samples were collected from the cephalic vein at time intervals of 30 minutes, 1, 2, 4, 8, 24 and 48 hours and 7 and 20 days following drag administration and their sera separated. Concurrent urine samples were examined by urine strip. Serumic levels of urea, creatinine, total protein and albumin were measured by colorimetric method using spectrophotometer and commercial diagnostic kits. The results of this study demonstrated significant increase (p<0.05) in serumic levels of urea, creatine, total protein, albumin and urine specific gravity up to 8 hours following drag administration that could be due to the effect of drag on body water and creation of dehydration whereas alter this time significant decrease in serumic levels of total protein and albumin and also significant increase of serumic levels of urea and creatinine was observed alongside proteinuria and albuminuria due to the effect of drag or its metabolite on the kidney. Therefore even a single consumption of the drag could have deleterious effects on normal kidney function and homeostasis.

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