The mechanical performance of silk and collagen nanoparticles for dental applications

Subject Areas : Journal of Simulation and Analysis of Novel Technologies in Mechanical Engineering

Mohammad Hossein Malekipour Esfahani ¹ , Behnoush Selahbarzin ²

1 - Dental Students Research Center, School of Dentistry, Isfahan University of Medical Sciences, Isfahan, Iran
2 - Lorestan Dental Department

Received: 2022-10-28 Accepted : 2023-02-19 Published : 2023-03-01

Keywords: Mechanical Properties, Silk, Tricalcium phosphate, Drug/gene carriers,

Abstract :

Today, great interest has been generated by dental science and engineering researchers to use bio-based nanoparticles to deliver therapeutic molecules such as drugs, genes, and tissue engineering. Controlling particle size, charge, surface morphology and release rate of loaded molecules is important for using nanoparticles based on biopolymers and bioactive ceramics such as tricalcium phosphates (TCP) as drug/gene carriers. Recently, drug release systems and nanoparticle systems have attracted much attention as suitable carriers. Drug delivery systems are methods used to ensure that drugs reach the required areas in the body. Natural polymers such as proteins have attracted a lot of attention due to their biocompatibility properties with living organisms. Among polymers, silk fibers have attracted the attention of researchers in the field of textiles and medicine due to their good properties such as low specific gravity, strength and high thermal resistance. In addition, their use as carriers of drugs, therapeutic genes and biomaterials for tissue engineering with applications in the field of dental and orthopedic materials has been reviewed.

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