Investigation of cell biomechanics and the effect of biomechanical stimuli on cancer and their characteristics

Subject Areas : Journal of Simulation and Analysis of Novel Technologies in Mechanical Engineering

Atefeh Ghorbani ¹ , Sheyda Shahriari ² , Amir Mohammad Gholami ³

1 - Biotechnology Department., Falavarjan Branch, Islamic Azad University, Isfahan, Iran
2 - Institute of Psychiatry, Psychiatry and Neuroscience, Kings College London, London, UK
3 - Department of Mechanical Engineering, Najafabad Branch, Islamic Azad University, Najafabad, Iran

Received: 2022-01-20 Accepted : 2022-04-11 Published : 2021-11-01

Keywords: biomechanics, Cell, Cell biomechanics, Mechanical stimulation,

Abstract :

Physical stimuli have a great impact on the survival, behavior, and function of all life. Recently, a theory has been proposed to understand cellular behavior in times of failure and disease, stating that cellular processes and damage can be affected by mechanical forces. Scientific evidence suggests that mechanical changes can affect many of the primary cellular mechanisms, as well as important aspects of cell behavior such as cell adhesion, movement, and signal transmission. In this study, we examine the history of the effects of mechanical stimulation from the beginning to the present, what is cell biomechanics, introduce features and methods to study cell characteristics such as micropipette suction and atomic force microscopy (AFM). In addition, to consider the effects of biomechanical stimulation it should be point out to cells using stimuli which can be useful including inducing differentiation into stem cells to produce bone cells that are applied by special devices that are briefly examined for the beneficial effects. It also has negative aspects for the cell, such as the occurrence of metastases in cancer cells. In this work, the effect of changes in the inclination, frequency and strain on the cancer cell was also investigated.

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