The effect of aerobic interval training and alpha-lipoic acid supplementation on serum irisin, visfatin and insulin resistance in diabetic rats
Subject Areas : Effect of Physical Activity on DiseasesMohammadmehdi Jafari 1 , amin Farzaneh hesari 2 * , Niloofar Dastjerdi 3
1 -
2 - Department of Exercise Physiology, Sari Branch, Islamic Azad University, Sari, Iran
3 - Department of Exercise Physiology, Sari Branch, Islamic Azad University
Keywords: Diabetes, Interval training, Anti oxidant, Irisin, visfatin,
Abstract :
Background and Objectives: Exercise training and drug interventions, especially herbal medicines, are considered as best approaches to improving the health status of diabetic patients. Alpha lipoic acid (ALA) is a powerful biological antioxidant. However, the role of exercise training and ALA on IAPP are not well understood. The aim of this study was to investigate the effect of moderate-intensity interval training and ALA supplementation on serum irisin, visfatin and insulin resistance in type 2 diabetic rats. Materials and Methods: In this experimental study, 42 Wistar rats (average and age of 12 weeks and weight of 230 ±8 grams) were randomly assigned to 6 groups: control, diabetic, salin, supplementation, training and training+supplementation. Diabetes was induced by intra-peritoneal injection of streptozotocin. The training program included 8 weeks, three sessions per week, and each session with 10 periods of one minutes activity at 70% maximum speed and two minute rest. Moreover, ALA was administered orally 20 mg/kg once a day by gavage. The outcome data was analyzed using one-way analysis of variance and significance level of (P≤0.05). Findings: The results showed that irisin levels increased significantly in training, supplementation and supplementation+training groups than diabet group (P=0.001). Visfatin (P=0.021), Glucose and insulin-resistance significantly decreased in training and supplementation+ training groups than control group (P=0.011, P=0.008 respectively). Conclusion: It seems that combination of moderate intensity interval training and Alpha lipoic acid can have a positive effect on diabetes control by increasing irisin and decreasing visfatin, glucose and insulin- resistance levels.
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