Investigation of Effect of Heat Treatment on Produced Phases in 45S5 Glass-Ceramics Synthesized in the Forms of Powder and Pellet, and Investigation of Their Bioactivity

Subject Areas : journal of New Materials

Mohamadreza Masjedi ¹ , Babak Hashemi ²

1 - Department of Material Engineering, Faculty of Engineering, Shiraz University, Shiraz, Iran
2 - Department of Material Engineering, Faculty of Engineering, Shiraz University, Shiraz, Iran

Received: 2017-08-22 Accepted : 2019-01-31 Published : 2019-01-21

Keywords: Biomaterials, 45S5 Bioactive Glass-Ceramic, Sodalime Glass, Solid State Reaction, Bioactivity,

Abstract :

45S5 bioglass was synthesized by solid state reaction method using sodalime glass, calcium carbonate, sodium carbonate and phosphor pentoxide. XRF analysis was used to determine the glass composition, and Based on its results, the required amounts of other precursors were calculated and added to sodalime glass powder in order to obtain 45S5 composition. After that samples in the forms of powder and pellet were heat treated at different temperatures (800-1000ºC). DTA and XRD analysis were done to investigate thermal and phase properties of the samples. Crystallization temperature was determined to be 690ºC. Ca2Na2Si3O9 and CaNaPO4 crystalline phases were detected in all the samples. In-vitro bioactivity of samples was investigated by immersion of samples in SBF solution and further study of them by XRD and SEM analysis. Bioactivity of the samples was proved by determining HA layer formation on their surfaces. Results showed that Heat treatment temperature had more significant effect on the formation of crystalline phases than its time. Bioactivity of the sample heat treated at 1000ºC for 8hr was better than other samples heat treated at lower temperatures.

References:

References:

1-J. Y. Wong and J. D. Bronzino, Biomaterials: CRC Press, 2007.  

2-B. D. Ratner, A. S. Hoffman, F. J. Schoen, and J. E. Lemons, Biomaterials Science: An Introduction to Materials in Medicine: Elsevier Science, 2004. 

3-E. El-Meliegy and R. van Noort, Glasses and Glass Ceramics for Medical Applications: Springer New York, 2011.

4-L. L. Hench, An Introduction to Bioceramics, 2013.        

5-P. De Aza, A. De Aza, P. Pena, and S. De Aza, "Bioactive glasses and glass-ceramics," Boletin de la Sociedad Espanola de Ceramica y Vidrio, vol. 46, pp. 45-55, 2007.

6-L. L. Hench, "The story of Bioglass®," Journal of Materials Science: Materials in Medicine, vol. 17, pp. 967-978, 2006.  

7-L. L. Hench and J. Wilson, An Introduction to Bioceramics: World Scientific, 1993.     

8-H. A. ElBatal, E. M. A. Khalil, and Y. M. Hamdy, "In vitro behavior of bioactive phosphate glass–ceramics from the system P2O5–Na2O–CaO containing titania," Ceramics International, vol. 35, pp. 1195-1204, 4// 2009.        

9-L. Lefebvre, J. Chevalier, L. Gremillard, R. Zenati, G. Thollet, D. Bernache-Assolant, and A. Govin, "Structural transformations of bioactive glass 45S5 with thermal treatments," Acta Materialia, vol. 55, pp. 3305-3313, 6// 2007.

10-T. Kokubo, Bioceramics and their clinical applications: Elsevier, 2008.

11-L. L. Hench, "Biomaterials: a forecast for the future," Biomaterials, vol. 19, pp. 1419-1423, 1998.      

12-P. Li, Q. Yang, F. Zhang, and T. Kokubo, "The effect of residual glassy phase in a bioactive glass-ceramic on the formation of its surface apatite layerin vitro," Journal of materials science: Materials in medicine, vol. 3, pp. 452-456, 1992.

13-O. Peitl Filho, G. P. LaTorre, and L. L. Hench, "Effect of crystallization on apatite-layer formation of bioactive glass 45S5," J Biomed Mater Res, vol. 30, pp. 509-14, Apr 1996.   

14-O. Peitl, E. D. Zanotto, and L. L. Hench, "Highly bioactive P2O5–Na2O–CaO–SiO2 glass-ceramics," Journal of Non-Crystalline Solids, vol. 292, pp. 115-126, 2001.           

15-H. Arstila, L. Hupa, K. H. Karlsson, and M. Hupa, "Influence of heat treatment on crystallization of bioactive glasses," Journal of Non-Crystalline Solids, vol. 354, pp. 722-728, 1/15/ 2008.       

16-H. Arstila, E. Vedel, L. Hupa, and M. Hupa, "Factors affecting crystallization of bioactive glasses," Journal of the European Ceramic Society, vol. 27, pp. 1543-1546, // 2007.      

17-Q. Z. Chen, I. D. Thompson, and A. R. Boccaccini, "45S5 Bioglass®-derived glass–ceramic scaffolds for bone tissue engineering," Biomaterials, vol. 27, pp. 2414-2425, 4// 2006. 

18-A. R. Boccaccini, Q. Chen, L. Lefebvre, L. Gremillard, and J. Chevalier, "Sintering, crystallisation and biodegradation behaviour of Bioglass®-derived glass–ceramics," Faraday discussions, vol. 136, pp. 27-44, 2007.           

19-R. Huang, J. Pan, A. Boccaccini, and Q. Chen, "A two-scale model for simultaneous sintering and crystallization of glass–ceramic scaffolds for tissue engineering," Acta biomaterialia, vol. 4, pp. 1095-1103, 2008.          

20-O. Bretcanu, C. Samaille, and A. R. Boccaccini, "Simple methods to fabricate Bioglass®-derived glass–ceramic scaffolds exhibiting porosity gradient," Journal of Materials Science, vol. 43, pp. 4127-4134, 2008.         

21-L. Lefebvre, L. Gremillard, J. Chevalier, R. Zenati, and D. Bernache-Assolant, "Sintering behaviour of 45S5 bioactive glass," Acta biomaterialia, vol. 4, pp. 1894-1903, 2008.    

22-Q. Chen, A. Efthymiou, V. Salih, and A. Boccaccini, "Bioglass®‐derived glass–ceramic scaffolds: Study of cell proliferation and scaffold degradation in vitro," Journal of biomedical materials research Part A, vol. 84, pp. 1049-1060, 2008.

23-S.-C. Wu, H.-C. Hsu, S.-H. Hsiao, and W.-F. Ho, "Preparation of porous 45S5 Bioglass®-derived glass–ceramic scaffolds by using rice husk as a porogen additive," Journal of Materials Science: Materials in Medicine, vol. 20, pp. 1229-1236, 2009.       

24-O. Bretcanu, X. Chatzistavrou, K. Paraskevopoulos, R. Conradt, I. Thompson, and A. R. Boccaccini, "Sintering and crystallisation of 45S5 Bioglass® powder," Journal of the European Ceramic Society, vol. 29, pp. 3299-3306, 2009.  

25-R. L. Siqueira and E. D. Zanotto, "Facile route to obtain a highly bioactive SiO2–CaO–Na2O–P2O5 crystalline powder," Materials Science and Engineering: C, vol. 31, pp. 1791-1799, 2011.

26-M. Abbasi and B. Hashemi, "Fabrication and characterization of bioactive glass-ceramic using soda–lime–silica waste glass," Materials Science and Engineering: C, vol. 37, pp. 399-404, 4/1/ 2014.

27-T. Kokubo and H. Takadama, "How useful is SBF in predicting in vivo bone bioactivity?," Biomaterials, vol. 27, pp. 2907-2915, 2006. 

28-J. Gamble, "Physiology and pathology of extracellular fluid—a lecture syllabus," ed: Cambridge: Harvard University Press, 1949.          

29-L. A. Adams, E. R. Essien, R. O. Shaibu, and A. Oki, "Sol-gel synthesis of SiO2-CaO-Na2O-P2O5 bioactive glass ceramic from sodium metasilicate," New Journal of Glass and Ceramics, vol. 3, p. 11, 2013.

30-S. Jalota, S. B. Bhaduri, and A. C. Tas, "A new rhenanite (β‐NaCaPO4) and hydroxyapatite biphasic biomaterial for skeletal repair," Journal of Biomedical Materials Research Part B: Applied Biomaterials, vol. 80, pp. 304-316, 2007.

31-P. McMillan, "Glass-ceramics 2nd ed," Non-Metallic Solids, 1979.        

32-M. Dziadek, B. Zagrajczuk, E. Menaszek, K. Dziadek, and K. Cholewa-Kowalska, "Poly (ε-caprolactone)-based membranes with tunable physicochemical, bioactive and osteoinductive properties," Journal of Materials Science, vol. 52, pp. 12960-12980, 2017.        

33-G. Poologasundarampillai, D. Wang, S. Li, J. Nakamura, R. Bradley, P. Lee, M. Stevens, D. McPhail, T. Kasuga, and J. Jones, "Cotton-wool-like bioactive glasses for bone regeneration," Acta biomaterialia, vol. 10, pp. 3733-3746, 2014.  

34-D. Clupper and L. Hench, "Crystallization kinetics of tape cast bioactive glass 45S5," Journal of non-crystalline solids, vol. 318, pp. 43-48, 2003.