Synthesis and Characterization of Temperature‐Sensitive Hydrogel Copolymer Based on N-isopropylacrylamide for Medical Applications

Subject Areas : journal of New Materials

M. R Rayati Shavazi ¹ , محبوبه Mahmoodi ² , نوید Nasirizadeh ³

1 - گروه مهندسی پزشکی، واحد یزد، دانشگاه آزاد اسلامی، یزد، ایران
2 - گروه مهندسی پزشکی، واحد یزد، دانشگاه آزاد اسلامی، یزد، ایران
3 - گروه مهندسی پلیمر، واحد یزد، دانشگاه آزاد اسلامی، یزد، ایران

Received: 2015-04-04 Accepted : 2017-06-17 Published : 2017-05-22

Keywords: N-isopropyl acrylamide, Temperature‐Sensitive Hydrogel, Copolymer, Radical polymerization,

Abstract :

      In this study, temperature-sensitive hydrogel copolymer based on N- isopropyl acrylamide macromolecule synthesized and characterized. The confirming successfulness of copolymer synthesis by radical polymerization method was carried out by fourier transform infrared spectroscopy (FTIR) and hydrogen nuclear magnetic resonance (H-NMR). The gelation behavior and viscoelastic properties of hydrogel copolymer were tested by rheology test. Lower critical solubility temperature (LCST) of samples was calculated using differential scanning calorimeter (DSC) at 30°C. Also, the rate of swelling of temperature‐sensitive hydrogel calculated 80%. Rheological studies and temperature analysis showed increasing the temperature to 60°C that it results in production of stable phases. Therefore, this hydrogel designed according to the temperature-sensitive component can be considered as a potential candidate for medical applications. 

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