Thermodynamic, spectral and antimicrobial activity of inclusion complexes of acridone and its oxime with β-cyclodextrin

Subject Areas : Journal of the Iranian Chemical Research

Swapna Sankar Nayak ¹ , Sunakar Panda ²

1 - PG Department of Chemistry, Berhampur University, Bhanja Vihar 760007, India
2 - S.B.R. Govt. Women’s (Auto) College, Berhampur 760001, India

Received: 2009-06-10 Accepted : 2009-11-09 Published : 2009-12-31

Keywords: Acridone, Inclusion complex, β-cyclodextrin, Thermodynamic stability, Antimicrobial study,

Abstract :

One of the methods to enhance bio-accessibility of drugs like Acridone and its oxime is toform inclusion complexes with β-cyclodextrin. The formation of such complexes has beenconfirmed by changes in spectral characteristics and melting point data. The aqueous phasesolubility studies reveal 1:1 stoichiometry between the compound and, β-cyclodextrin. The studyof thermodynamic parameters like ΔG, ΔH, ΔS indicates the inclusion complex formation to beexothermic and spontaneous. The study of antimicrobial activity of these compounds indicatesthat the microbes like E. coli and P. aeruginosa are susceptible and the susceptibility increasessignificantly after formation of inclusion complex.

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