Antiplasmodial ativity of akaloids from Garcinia Parvifolia Miq. Stem Bark

Subject Areas : Journal of the Iranian Chemical Research

U.Z. Lathifah ¹ , R.A. Rahima ² , H. Sudrajat ³ , S. Khairi ⁴

1 - Advance Medical & Dental Institute, Suite 121, EUREKA Complex,Universiti Sains Malaysia, Minden 11800, Penang, Malaysia
2 - Advance Medical & Dental Institute, Suite 121, EUREKA Complex,Universiti Sains Malaysia, Minden 11800, Penang, Malaysia
3 - Ikatan Mahasiswa Eksakta Indonesia, Barek, Sleman 55281, Yogyakarta, Indonesia
4 - Ikatan Mahasiswa Eksakta Indonesia, Barek, Sleman 55281, Yogyakarta, Indonesia

Received: 2009-07-27 Accepted : 2009-11-03 Published : 2010-12-31

Keywords: Isoquinoline alkaloids, Garcinia Parvifolia Miq, Antiplasmodial,

Abstract :

Garciniavalline (1), a novel aporphinoid alkaloid, in addition to four known alkaloids,cleistopholine (2), O-methylmoschatoline (3), (-)-oliveroline (4) and (-)-oliveridine (5), wereisolated and characterized from Garcinia Parvifolia Miq. stem bark. Structural elucidation ofthese compounds was established by spectroscopic methods. Among them, alkaloids (2) and (4)exhibited antiplasmodial activity against Plasmodium falciparum

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