A review of pharmacological properties and functional of Cinnamon
Subject Areas : Journal of Medicinal Herbs, "J. Med Herb" (Formerly known as Journal of Herbal Drugs or J. Herb Drug)
امیرپویا
قندهاری یزدی
1
(گروه علوم و صنایع غذایی، دانشکده کشاورزی، دانشگاه آزاد اسلامی واحد شهرکرد، شهرکرد، ایران؛)
آلاله
نیکویی
2
(گروه علوم و صنایع غذایی، دانشکده کشاورزی، دانشگاه آزاد اسلامی واحد شهرکرد، شهرکرد، ایران؛)
لیلا
صداقت بروجنی
3
(گروه علوم و صنایع غذایی، دانشکده کشاورزی، دانشگاه آزاد اسلامی واحد شهرکرد، شهرکرد، ایران؛
عضو باشگاه پژوهشگران جوان، دانشگاه آزاد اسلامی واحد شهرکرد، شهرکرد، ایران؛)
Keywords: Reproduction, Antioxidant, Cinnamon, Diabetes, Fibrinolytic, Reduce of pain,
Abstract :
Background & Aim: Considering the inevitable side effects of chemical drugs, nowadays, herbal medicine has gained a special importance. Cinnamon of Lauraceae Family, is commonly used as a food spice and medicine. It is famous to be, antimicrobial, anti-oxidant, anti-diabetic, anti-viral, and antispastic. It also prevents abdominal bloating, increases sweating and uterus muscle constrictions. Cinnamon’s essence is known to have anti-fungal and antibacterial effects, which most presumably reflects the presence of ortho methoxy cinnamic aldehyde components in it (OR which is due to the presence of ortho methoxy cinnamic aldehyde components). Cinnamon extracts contain eugenol compounds which characterizes the fibrinolytic effects of it.Furthermore, Cinemon and its derivatives can also influence the central nervous system and alleviate the pain. Additionally, cinnamon compounds can influence insulin effects and reduce the insulin resistance and consequently result in positive effects on blood sugar level. One of its most important effects is the effect on increased sexual drive. Direct or indirect effect of cinemon compounds in increasing hormonal production and release could well be due to increase of nitric acid synthesis. It also contains volatile and non-volatile non-phenolic ingredients that most probably bring about its anti-oxidant effects. Recommended applications/industries: Considering the mentioned effects of cinnamon and its extracts and additional ease of extraction and its cost effectiveness, it can be easily used in pharmaceutical and food industries. In food industry, it's anti-microbial and anti-oxidants effects and even for packaging strategies as a natural conservator cinnamon can be an effective candidate.
Abdolmaleki, M., Salari, M., Bahrami nejad, S., Panjeke, N., Abasi, S. 2008. Antifungal activity of cinnamon (Cinnamomum zelanicum) crude extracts against some phytopathogenic fungi. Plant diseases., 44.
Amoeian, B., Nouri baiat, Sh., Moulana, Z., Moghadamnia, A. A., Asgharpour, F. 2014. Assessment of antibacterial effect of cinnamon on growth of porphyromons gingivalis in chronic periodontitis patients with deep pockets. Journal of Dentistry, Tehran University of Medical Sciences and Health Services, Tehran., 27(1): 8-15.
Angmor, J. E., Dicks, D. M., Evans, W. C. & Santra, D. K. 1972. Studies on Cinanammun zeylancum. Planta medica., 21: 416-420.
Akhavan amjadi, M., Mojab, F., Shahbaz zadegan, S. 2009. Effect of cinnamon on primary dysmenorrhea and symptoms. Journal ofArdabilUniversityof Medical Sciences., 9(3): 204-209.
Ataei, Z., Ansari, M., Mousavi, M., Mirzaei, A. 2007. Experimental study of the antifungal effect of extracts of wormwood, eucalyptus, onion, cinnamon, turmeric, sage, mint, calendula the standard strain of Candida albicans in comparison with nystatin mouthwash. Journalof Islamic Dental Association., 19(2): 91-97.
Arbabi, K., Shirazi, M., Pourzamani, M., Dabiri, S. 2011. Comparing the effect of vegetable extracts of Thyme, Clove and Cinnamon on Inhibition of Candida albicans to nystatin. Journalof Research inDentalScience., 8(4): 175-179.
Blevins, S. M., Leyva, M. J., Brown, J., Wrlght, J., Scofield, R. H., Aston, C. E. 2007. Effect of cinnamon on glucose and lipid levels in non insulin-dependent type 2 diabetes. Diabetes care., 30: 2236-2237.
Chaudhry, N. M. A., Tariq, P. 2006. Anti-microbial activity of cinnamomum cassia against diverse microbial flora with its nutritional and medicinal impacts. Pakistan Journal of Botany., 38: 169.
Daferera, D. J., Ziogas, B. N. & Polissou, M. G. 2000. GC-MS analysis of essential oils from some Greek aromatic plants and their fungitoxicity on Penicillium digitatum. Journal of Agricultural and Food Chemistry., 48: 2576-2581.
Desmit, P. A. G. M., Keller, K., Hansel, R., Chandler, R. F. 1992. Adverse effects of herbal drugs. Volume 1, Springer-Verlag.
Eslami, G., Falah, F., taheri, S., Navidinia, M., Dabiri, H., Dadashi, M., Zahirnia, Z. 2012. Evaluation of antibacterial activity of cinnamon extract on Helicobacter pylori isolated from
Patients with dyspepsia. Journal of the Faculty of Medicine., 37(2):85-89.
Firouzbakhsh., Afsarian, M. H., Hooshangi, S., Badali, H. 2014. Evaluation of in vitro antifungal activity of Foeniculum, Achillea, Satureja, Cinnamomum and Artemisia against Saprolegnia parasitica, Arak Medical University Journal., 17(86): 60-69.
Friedman, M., Henika, P. R., Mandrell, R. E. 2002. Bactericidal activities of plant essential oils and some of their isolated constituents against Campylobacter jejuni, Escherichia coli, Listeria monocytogenes, and Salmonella enterica. Journal of Food Protection., 65:1545-1560.
GReenberg, M. J. & Johnson, S. S. 1995. Method for refining mint oils and chewing gum made from same.
Hefnaway, Y. A., Moustaa, S. I., Marth, E. H. 1993. Sensitivity of Listeria monocytogenes to selected spices. Journal of food protection (USA)., 65:876-878.
Hematkhah, F. 2013. Herbal Medicines. Electronic book., 48.
Hosseini, N., Malekirad, A., Changizi Ashtiani, S., Nazemi, M. 2012. Free radicals scavenging Activity of essential oils and different fractions of methanol extract of Zaataria multiflora, Savia officinalis, Rosmarinus officinalis, Mentha pulegium and Cinnamomum zeylanicum. Journal of Shahid sadoughi university of medical sciences., 20(1): 28-38.
Jamshidi, M., Barzegar, M., Sahari, M. 2013. Effect of gamma irradiation on the antioxidant and antimicrobial activities of cinnamon powder. Iranian journal of Nutrition Sciences & Food Technology., 7(4): 73-82.
Loesche, W. j., 1991. Role of anaerobic bacteria in periodontal diseases. The Annals of
otology, rhinology & laryngology. Supplement., 154: 43-45.
Kamaliroosta, L., Ghavami, M., Gharachorloo, M., Azizinezhad, R., 2010. Isolation of cinnamon extract and assessing its effect on the stability of sunflower oil. Iranian journal of Nutrition Sciences & Food Technology., 6(1):13-22.
Kamaliroosta, L., Ghavami, M., Elhamirad, A. H., Azizinezhad, R., 2014. Evaluation of the Antioxidant and Chelating Activities of Cinnamon Extract. Food Technology & Nutrition., 11(2):37-46.
Khan, A., Safdar, M., Khan, M. M. A., Khattak, K. N., Anderson, R. A. 2003. Cinnamon improves glucose and lipids of people with type 2 diabetes. Diabetes care., 26: 3215-3218.
Kim, J. M., Marshall, M. R., Cornell, J. A., JF, P., WEI, C. I. 1995. Antibacterial activity of carvacrol, citral, and geraniol against Salmonella typhimurium in culture medium and on fish cubes. Journal of Food Science, 60., 1364-1368.
Kim, S. H., Hyun, S. H., Choung, S. Y. 2006. Anti-diabetic effect of cinnamon extract on blood glucose in db/db mice. Journal of ethnopharmacology., 104: 119-123.
Lee, S. K., Hong, C. H., Huh, S. K., Kim, S. S., OH, O. J., Min, H. Y., Park, K. K., Chung, W. Y., Hwang, J. K. 2002. Suppressive effect of natural sesquiterpenoids on inducible cyclooxygenase (COX-2) and nitric oxide synthase (iNOS) activity in mouse macrophage cells. Journal of environmental pathology, toxicology and oncology., 21.
Lee, H. J., Hyun, E. A., Yoon, W. J., Kim, B. H., Rhee, M. H., Kang, H. K., Cho, J. Y., Yoo, E. S. 2006. In vitro anti-inflammatory and anti-oxidative effects of Cinnamomum camphoraextracts. Journal of ethnopharmacology., 103(2): 208-216.
Mang, B., Wolters, M., SchmittI, B., Kelb, K., Lichtinghagen, R., Stichtenoth, D. O., Hahn, A. 2006. Effects of a cinnamon extract on plasma glucose, HbA1c, and serum lipids in diabetes mellitus type 2. European journal of clinical investigation., 36: 340-344.
Mancini-Filho, J., Van-Kollj, A., Mancini, D. A., Cozzolino, F. F., Torres, R. P. 1998. Antioxidant activity of cinnamon (Cinnamomum Zeylanicum, Breyne) extracts. Bollettino chimico farmaceutico., 137: 443-447.
Mathew, S., Abraham, T. E. 2006. Studies on the antioxidant activities of cinnamon (Cinnamomum verum) bark extracts, through various in vitro models. Food Chemistry., 94: 520-528.
Mirheidar, H. 2004. Plant knowledge; Application of plants in prevention and remedy of diseases. Tehran, Islamic Culture Press., 323-328.
Modaresi, M., Mesripour, M., Rajaei, R. 2009. The effect of cinnamon extract on Male Reproductive phisiology in mice. Armaghane-danesh bimonthly journal of Yasug university of medical sciences., 14(1): 67-77.
modaresi, M., Mesripour, M., Toghiani, M., Rahhaei, R.2010. Effect of hydroalcoholic extract of Cinnamon zeylanicum pituitary axis - the testes of mice. Journal ofGorganUniversityof Medical Sciences., 12(1):15-19.
Mohammad Beigi, N., Haghighi Asl, A., Hormozi, f. 2008. Investigation of various factors Drasansgyry of cinnamon. College of Engineering., 42(2):199-203.
Mohammadifar, Sh. 2010. The origin, history and trade routes cinnamon. History of Science., 9:51-37.
Naderi, G. H. A., Jafari dinani, N., Nejabat, N., Kelardasht, M., Jafarian dehkordi, A., Asgari, S., Shami, R. 2009. Fibrinolytic activity of polyphenolic extract of Turmeric (Curcuma domestica valet), Angelica (Heracleum persicum Desf. Ex Fischer), cinnamon (Cinnamomum verum J.Presl) and Thymus vulgaris (Zataria multiflora .Boiss) in vitro. Quarterly Scientific Research of Medicinal and Aromatic Plant., 25(4): 572-580.
Nevas, M., Korhonen, A. R., Lindstrom, M., Turkki, P. & Korkeala, H. 2004. Antibacterial efficiency of Finnish spice essential oils against pathogenic and spoilage bacteria. Journal of Food Protection, 67: 199-202.
Nostro, A., Germano, M. P., Dangelo, V., Marino, A., Cannatelli, M. A. 2000. Extraction methods and bioautography for evaluation of medicinal plant antimicrobial activity. Letters in Applied Microbiology., 30: 379-384.
Parvizi, M.R. 2007. The study complementary effects of Cinnamon on hypoglycemia induced by insulin in male diabetized rats using sterptozotocin. Annals of military and health sciences research., 5(1):1101-1104.
Rahnama, M., Asghari, M. 2012. Antimicrobial effects of plant essential oilsrosemary, cinnamon, oreganoand cumin, alone and in combination with nisin against Salmonella typhimurium. Journal of Zoonoses Research .,1(1): 22-28.
Rafati, A. R., Hashemi, S. S., Koohi Hosseinabadi. 2013. Effect of Cinnamon extract on Cerebellum on Histomorphometry in Diabetic Rats Fetus. Armaghan-danesh, yasuj university of medical sciences journal.18(6):463-474.
Rashidolmir, A., Alizadeh, A., Ebrahimi atri, A., Dastani, M. 2011. Effect of 4 weeks of aerobic exercise with the Consumption of cinnamon on lipoprotein parameters and blood glucose in type II diabetic women. Shahid SadoughiUniversityofMedical Sciencesand Health Services., 20(5):605-614.
Safdar, M., Khan, A., Khattak, M. M. A. K., Siddique, M. 2004. Effect of various doses of cinnamon on blood glucose in diabetic individuals. Pakistan Journal of Nutrition., 3(5): 268-272.
Shah, A. H., AL-Shareef, A. H., Ageel, A. M., Qureshi, S. 1998. Toxicity studies in mice of common spices, Cinnamomum zeylanicum bark and Piper longum fruits. Plant Foods for Human Nutrition., 52: 231-239.
Sheikh, N., Safari, M. R., Araghchian, M., Zeraati, F. 2003. Effects of cinnamon, sumac and pepper on albumin glycation reactions. Journal of Medicinal Plants., 7: 1-17.
Singh, N., Singh, R. K., Bhunia. A., Stroshine, R. L. 2002. Efficiacy of chlorine dioxide ozone and thyme essential oil or a sequential washing in killing E. coli O157: H7 on letteuce and baby carrots. Lebensmittel-Wissenschaft & Technologie., 33: 720-729.
Skandamis, P., Koutsoumanis, K., Fasseas, K., Nychas, G. E. 2001. Inhibition of oregano essential oil and EDTA on Escherichia coli O157: H7. Italian Journal of Food Science., 13: 65-75.
Ranjbarian, P., Sadeghian. S., Shirazi, M.H., Sarafnejad, A., Fazeli, M.R., Amin, Gh. R., Majlesi, A., Kashani, KH. M., Koraki, M. 2004. Study of the antibacterial effect of four herbal extracts of cinnamon, caraway, fennel and Sure on the HP disk diffusion method and flow cytometry. Journal of Hamadan University of Medical Sciences and Health Services., 11(3): 42-47.
Tabak, M., Armon, R., Potasman, I., Neeman, I. 1996. In vitro inhibition of Helicobacter pylori by extracts of thyme. Journal of applied bacteriology., 80: 667-672.
Vahidi, A., Dashti, M. H., Mojdeh, M., Soltani, H. R. 2012. Effect of cinnamon extract on learning and memory in mice. Medical Science Journalof Islamic Azad University., 22(2):105-109.
Zahmatkesh, M., Falah hosseini, H., Hajiaghaei, R., Heidari, M., Mehrafarin, A., Tavakolifar, B. 2011. Effect of cinnamon on glucose levels in type 2 diabetic patients, a double-blind clinical trial. Journal of Medicinal Plants., 11(1): 258-263.