Investigation of the frequency and clinical evaluation of co-infection of rotavirus with adenovirus and astrovirus

Subject Areas : Journal of Comparative Pathobiology

S.D Mousavi-Nasab, ¹ , مصطفی Ghaderi ² , فاطمه Zali ³ , Mardani, R Mardani ⁴ , هومن Kaghazian ⁵

1 - Department of Arboviruses and Viral Hemorrhagic Fevers, Pasteur Institute of Iran, Tehran, Iran
2 - Department of Microbiology, Karaj Branch, Islamic Azad University, Karaj, Iran
3 - Department of Clinical Biochemistry, Faculty of Medicine, Tehran University of Medical Science, Tehran, Iran
4 - Department of Clinical Biochemistry, School of Medicine, Hamedan University of Medical Sciences, Hamedan, Iran
5 - Department of Research and Development, Production and Research Complex, Pasteur Institute, Tehran, Iran

Received: 2022-12-22 Accepted : 2023-03-11 Published : 2023-03-11

Keywords: Gastroenteritis, Diarrhea, Rotavirus-astrovirus, Astrovirus,

Abstract :

Viral gastroenteritis is one of the most common ailments in all age groups acrosdxdxs the globe, and more than 700 million cases of diarrhea occur in children under five years of age. Rotavirus, norovirus, adenovirus and astrovirus are important causes of acute viral gastroenteritis. Co-infection studies have been conducted in Iran in the past, but these studies were limited and heterogeneous. The purpose of this study is to investigate the frequency of co-infection of rotavirus with astrovirus and adenovirus and to investigate clinical parameters such as fever, duration and severity of diarrhea in positive cases of co-infection. In this article, the co-infection of rotavirus with adenovirus and astrovirus among 28 rotavirus positive samples collected from children under five years of age with gastroenteritis was investigated by molecular method. The frequency of simultaneous rotavirus-adenovirus infection was two and rotavirus-astrovirus infection was observed in four children. In addition to this, the documentation available in the patients' files and its relationship with the objectives of the current study show that the positive results of simultaneous infection only increased the duration of diarrhea and did not cause other specific symptoms such as duration of fever and severity of diarrhea. In this study, the sample size was low, but according to the results, it can be said that the current study shows the importance of simultaneous diagnosis of viral diarrhea factors in order to predict the duration of diarrhea and the possibility of other clinical symptoms.

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