Investigating the regenerative effects of PRP and polycaprolactone-hydroxyapatite zeolite nanocomposites on wound healing after tooth extraction

Subject Areas : Journal of Comparative Pathobiology

علیرضا Sagart ¹ , علیرضا Jahandideh ² , احمد Asghari ³ , ابوالفضل Akbarzadeh ⁴ , پژمان Mortazavi ⁵

1 - Department of Clinical Science, Science and Research Branch, Islamic Azad University, Tehran, Iran.
2 - Department of Clinical Science, Science and Research Branch, Islamic Azad University, Tehran, Iran.
3 - Department of Clinical Science, Science and Research Branch, Islamic Azad University, Tehran, Iran.
4 - 2- Drug Applied Research Center, Tabriz University of Medical Sciences,
5 - Department of Pathobiology, Science and Research Branch, Islamic Azad University, Tehran, Iran.

Received: 2022-10-24 Accepted : 2023-02-10 Published : 2023-02-09

Keywords: Nanocomposite, Polycaprolactone-hydroxyapatit, Elongated tooth cavity, Wound Healing,

Abstract :

Wound healing after a tooth extraction is a complex process that helps repair wounds. Wound dressings are helpful for better healing. These agents should have the least inflammatory stimulation and the most antimicrobial properties. This study tried to investigate the effect of polycaprolactone-hydroxyapatite zeolite nanocomposites on the healing processes of the mucosa covering the alveoli after extraction. Fifteen healthy cats with lower premolar teeth caries were determined, and tooth extraction was performed. A biopsy sample was taken from the mucosa of the tooth extraction site on the 10th day after surgery. Premolar teeth of all 15 cats were extracted, and three groups were grouped as control, PRP, and nano polycaprolactone-hydroxyapatite zeolite. Histopathological analysis showed that unlike the control group and PRP, the nano group had a much better trend compared to the control group and the PRP group, with less presence of inflammatory cells, complete irregular epithelial tissue, more fleshy bud tissue, and more fibrosis. Polycaprolactone-hydroxyapatite zeolite nanocomposite accelerates wound healing after tooth extraction.

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