Study of the effect of nerolidol on Alzheimer's disease in Wistar rats

Subject Areas : Journal of Comparative Pathobiology

پیمان Taheri ¹ , پریچهره Yaghmaei ² , زهرا Hajebrahimi ³ , کاظم Parivar ⁴

1 - Department of Biology, Science and Research Branch, Islamic Azad University, Tehran, Iran
2 - Department of Biology, Science and Research Branch, Islamic Azad University, Tehran, Iran
3 - A&S Research Institute, Ministry of Science Research and Technology, Tehran, Iran
4 - Department of Biology, Science and Research Branch, Islamic Azad University, Tehran, Iran

Received: 2022-06-21 Accepted : 2022-08-25 Published : 2022-08-25

Keywords: Alzheimer’s, nerolidol, beta amyloid, oxidative stress,

Abstract :

Alzheimer's disease is the most important cause of dementia in human societies and the elderly population. One of the most important symptoms of this disease is amyloid plaques in the hippocampus. Inflammation and oxidative stress play an important role in the development of Alzheimer's disease. Nerolidol is one of the many metabolites of plants and has antioxidant and anti-inflammatory properties. Therefore, the aim of this study was to evaluate the effect of nerolidol on beta amyloid-induced model of Alzheimer's in rats. 48 male Wistar rats randomly divided into 8 groups including control, sham, streptozotocin induced model of Alzheimer's, Alzheimer's and drug solvent, Alzheimer's and treatment with donepezil, Alzheimer's and treatment with nrolidol dose 50, Alzheimer's and treatment with nrolidol dose 100 and protection groups (pre-treatment with nerolidol before Alzheimer's induction). Rats weight, catalase activity, and amount of amyloid plaque were measured. Histological studies were performed by fluorescent staining. Streptozotocin increased amyloid plaques, and decreased rat's weight and catalase activity. Donepezil and nerolidol, especially at doses of 100 and in the protective group, reduced the symptoms of Alzheimer's disease through weight gain, increased catalase activity, and decreased amyloid plaques. These findings show that nerolidol can be effective in improving Alzheimer's disease and its damage, and may possibly be effective in preventing Alzheimer's in people with a family history of Alzheimer's.

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