Study of the effect of supplement of soy isoflavone on the healing process of cutaneous wound in ovariectomized cats

Subject Areas : Journal of Comparative Pathobiology

, M Gholami ¹ , , HR Moslemi ² , , A Javaheri Vayeghan ³ , رضا Narenji Sani, ⁴

1 - Graduated from faculty of veterinary medicine, semnan university, semnan, Iran
2 - Department of clinical sciences, faculty of veterinary medicine, semnan university, semnan, Iran
3 - Department of Pathobiology, Faculty of Veterinary Medicine, Semnan University, Semnan, Iran
4 - Department of clinical sciences, faculty of veterinary medicine, semnan university, semnan, Iran

Received: 2019-06-10 Accepted : 2019-06-10 Published : 2019-05-22

Keywords: Soy isoflavone, Ovariectomy, Wound, Cat,

Abstract :

Sterilization surgery in dogs and cats is a common surgical procedure in veterinary medicine, which can be done in two ways: Ovariohysterectomy (OHE) and Ovariectomy (OVE). Since some diets in cats contain lots of Genistein and Daidzein, studying of the effect of soy isoflavone on the wound healing process is essential. In this study, 10 cats of the DSH, 1 year old, were used. OVE was done by midline approach. After surgery, cats divided into two groups including isoflavone and placebo. The isoflavone group received 50 mg of oral isoflavone daily. In the control group, placebo was used. After 14 and 28 days, biopsy of the surgical wound was taken for histopathological examination to evaluate the amount of collagen, angiogenesis and fibroblasts. Based on the findings, On Day 14 after injury, wound micrographs showed that there was no significant difference between treatment and control groups (p < /em> ≥ 0.05). Furthermore, on day 28 after the injury, the healing rate in the treatment group was higher than control group significantly (P≤0.05). In summary, results of this study showed that the application of supplement of soy isoflavone could improve the healing process of cutaneous wound in ovariectomized cats.

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