Histopathological study of the effect of pentoxifylline on experimental chronic non-bacterial prostatitis induced by carrageenan in rat

Subject Areas : Journal of Comparative Pathobiology

Hajighorbani, M., Ahmadi-hamedani, M. *, Shahab, E., Hayati, F., Kafshdoozan, K., Ghafari Kalili, S., Jebelli Javan, A. . ¹

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Received: 2018-04-13 Accepted : 2018-04-13 Published : 2018-03-21

Keywords: Chronic non-bacterial prostati, Histopathological criteria, Pentoxifylline, Rat,

Abstract :

Determination of histopathological criteria of chronic non-bacterial prostatitis (CNP), as the most common type of prostatitis syndrome, is highly effective to better understanding of pathophysiology and finding therapeutic strategies of this disease. Interest in pentoxifylline (PTX) has been renewed because of the anti-inflammatory and antioxidant potential of this drug. The aim of this study was to evaluate histopathological criteria of CNP in rat and to investigate the effectiveness of pentoxifylline on these criteria. Thirty male adult Wistar rats were divided into negative control, CNP control, standard and treatment groups. The negative control group received orally 1 ml saline normal for 21 consecutive days CNP was induced by single intraprostatic injection of 1% carrageenan (100 µl) in CNP control, standard and treatment groups. CNP control, standard and treatment groups received orally 1 ml saline normal, cernilton 100 mg/kg and PTX at 50 and 100 mg/kg 1 week after CNP induction for 21 consecutive days. Results showed that in the CNP control group, the PI was significantly increased as compared to negative control group (P<0.01). A significant reduction in the PI was observed in standard and treatment groups, especially PTX 50 mg/kg, in comparison with the CNP control group (P<0.05). Histopathological studies have shown a considerable improvement in the prostatic histoarchitecture in standard and treatment groups, especially PTX 50 mg/kg, in comparison with the CNP control group.

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