Comparative study on geometric and histopathologic effects of polar, semi polar and non-polar fractions Artemisia absinthium extract in rat
Subject Areas : Journal of Comparative Pathobiology
Rezaei, A., Mohajeri, D., Ahmadizadeh, Ch., Jalilzadeh, M. .
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Keywords: Artemisia absinthium, Polar, Semi polar, Non polar, Healing skin wounds, Rats,
Abstract :
Recovery of Scars is a treatment challenge in some diseases and chronic disorders. For this reason, new compounds are used for rapid recovery of Scars and conglutination. It is expected that Artemisia absinthium as a galenical and herbal drug, has rapid recovery effects in scars and sores because has anti- inflammation effects, activation of fibroblast cells and also antihyaluronidase effects cause the rapid recovery of sores. In this study, effects of Artemisia absinthium on recovery of sores as polar, semi polar and non-polar extractions of it are investigated on the rat as a second recovery. After anesthesia, with use of biopsy punch, Created circular sores with full thickness on the 70 female rats and recovery process were investigated in 5 groups. Drug administration and sores measures performed with analyzing of digital Scans, once a day for 21 days. For microscopic observations, gathered Samplings form this tissue in the 0, 3, 7, 14, 21 days, and microscopic symbols are ranged as edema factors and swelling reactions, hyperemia and bleeding, fibroblast, of Coverage tissue, torsion of sores and maturation of granular tissue. After histopathology and Calculation of recovery of sores scale for each drug, the finding results analyzed with SPSS software 17 versions. On the basis of geometric findings of recovery period, observed that semi polar extract of Artemisia absinthium has maximum Contraction of sores and control group has the least contraction of sores. Also, based on the histopathology results, total recovery in this group is better than other groups. In the second and third week. Recovered tissue has better organization than the other groups.