Antidiabetic effect of ethanolic extract of Salvia syriaca aerial parts in normal and streptozotocin-induced diabetic rats

Subject Areas : Journal of Comparative Pathobiology

Eidi, A. * . ¹

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Received: 2014-03-10 Accepted : 2014-07-21 Published : 2014-09-23

Keywords: Salvia Syriaca, Diabetes, Rat,

Abstract :

Many plants of genus Salvia are used for food products and medicine. The present study wasdesigned to examine the antidiabetic effect of Salvia syriaca ethanolic extract in normal andstreptozotocin-induced diabetic rats. Diabetes in rats was induced with a single injection ofstreptozotocin (70 mg/kg body weight) by intraperitoneal route. Salvia syriaca ethanolic extract(50, 100, and 200 mg/kg body weight) were administrated orally for 30 days. After 30 days, ratswere anesthetized and blood samples were collected. Serum glucose, insulin, triglycerides, totalcholesterol, urea, uric acid, creatinine, aspartate aminotransferase (AST) and alanineaminotransferase (ALT) levels in normal and streptozotocin-induced diabetic rats wereevaluated. Oral administration of Salvia syriaca ethanoic extract for 30 days exhibited asignificant reduction in serum glucose, triglycerides, total cholesterol, urea, uric acid, creatinine,AST, ALT and increased plasma insulin in streptozotocin-induced diabetic rats. Theadministration of extract did not change these serum parameters in normal rats. It is concludedthat Salvia syriaca has antidiabetic effect in rats and the plant should be considered as anexcellent candidate for future studies on diabetes mellitus.