Effects of Long-term administration of sildenafil citrate on serum markers of cardiac injury in the rats

Subject Areas : Journal of Comparative Pathobiology

Zarini, E., Amouoghli Tabrizi, B. *, Fartashvand, M., Sadeghy, R. . ¹

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Received: 2014-01-25 Accepted : 2014-06-18 Published : 2014-09-23

Keywords: Sildenafil citrate, Cardiac troponin I, Heart damage, Rat,

Abstract :

Nowadays, sexual impotence due to increased heart disease, has led to rising in consumption ofsexual enhancing drugs. In heart failure, due to decreased blood supply to corpus cavernosum,complete erection does not occur, which can lead to sexual dissatisfaction. One of the mostimportant drugs which are used to treat this disorder is sildenafil citrate, a selective inhibitor oftype 5 cGMP. The purpose of this study was to evaluate the long-term side effects of this drugon serum biomarkers of cardiac injury in the rat. In this study, 20 male Wistar rats wererandomly assigned into 2 groups including: control and treatment. In treatment group, sildenafilcitrate use at a dose of 100 mg/kg for 30 consecutive days in oral rout and control group onlyreceived Distilled water. At the end of experiment, the serum levels of cardiac troponin I,creatine kinase- MB, lactate dehydrogenase and aspartate aminotransferase were measured. Theresults obtained showed that sildenafil citrate has protective effects on cardiac enzymes whichmay be in association with releasing of nitric oxide (NO).